CRABP1 - cellular retinoic acid binding protein 1 Gene

Also Known as RBP5; CRABP; CRABPI; CRABP-I

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1381

About CRABP1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,340,353-78,348,225 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues and 15 paralogues. Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues.

Summary

This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

CRABP1 Products (1)

mRNA Protein Name
NM_004378.3 NP_004369.1 cellular retinoic acid-binding protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15607035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRABP1 Protein Structure

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (5 - 137)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

cellular retinoic acid-binding protein 1

  • cellular retinoic acid-binding protein I

CRABP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRABP1 P29762 TH Homo sapiens P07101-3
Y2H Array
32296183
Intra
CRABP1 P29762 TH Homo sapiens P07101-3
Y2H Prey Pooling
32296183
Intra
CRABP1 P29762 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross
CRABP1 P29762 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Pull Down
15607035
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRABP1 Proteins

Cat. No. Product Name Accession Purity
HY-P75687 CRABP1 Protein, Human P29762 (M1-E137) ≥ 95%, as determined by reducing SDS-PAGE.

CRABP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811362 CRABP1 Antibody WB, IHC-P Human, Mouse
HY-P82722 CRABP1 Antibody (YA2467) WB, IP Human, Mouse

Related Diseases

Diseases Alias
Teratocarcinoma

  • Mixed Embryonal Carcinoma And Teratoma
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Witkop Syndrome

  • Tooth And Nail Syndrome

  • Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome

  • Tns

  • Ectodermal Dysplasia 3, Witkop Type

  • ECTD3

  • Ectodermal Dysplasia 3, Tooth/Nail Type

  • Tooth-And-Nail Syndrome

  • Dysplasia Of Nails With Hypodontia

  • Nail Dysplasia With Hypodontia

  • Witkop'S Syndrome

  • Hypodontia - Dysplasia Of Nails

  • Hypodontia-Dysplasia Of Nails Syndrome

  • Hypodontia-Nail Dysgenesis Syndrome

  • Hypodontia-Nail Dysgenesis
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Keratoacanthoma

  • Ka - [Keratoacanthoma]

  • Well-Differentiated Squamous Cell Carcinoma
Hypervitaminosis A

  • Hypervitaminosis A, Susceptibility To

  • Hyperalimentation Of Vitamin A
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0444 Maprotiline hydrochloride 99.84% Unkown
HY-B0444R Maprotiline hydrochloride (Standard) 99.99% Unkown
HY-B0444A Maprotiline / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03134 CRABP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18859 Crabp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25351 Crabp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CRABP1 VGNC VGNC:27685
Felis catus CRABP1 VGNC VGNC:61155
Macaca mulatta CRABP1 VGNC VGNC:71480
Rattus norvegicus CRABP1 RGD RGD:2400
Mus musculus CRABP1 MGD MGI:88490
Others CRABP1 NCBI