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Epha4 - Eph receptor A4 Gene

Also Known as rb; Sek; Cek8; Hek8; Sek1; Tyro1; 2900005C20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13838

Summary

Enables GPI-linked Ephrin Receptor activity; identical protein binding activity; and transmembrane-ephrin receptor activity. Involved in several processes, including axon development; positive regulation of protein kinase activity; and regulation of neuron projection development. Acts upstream of or within adult walking behavior; axon guidance; and nephric duct morphogenesis. Located in several cellular components, including Schaffer collateral - CA1 synapse; early endosome membrane; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human EphA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Apr 2022]

Epha4 Products (1)

mRNA	Protein	Name
NM_007936.3	NP_031962.2	ephrin type-A receptor 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GPI-linked ephrin receptor activity	IMP IMP: Inferred from mutant phenotype	17143272	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16977320	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16977320	MGI
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	31439799	MGI
enables transmembrane-ephrin receptor activity	IDA IDA: Inferred from direct assay	17719550	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adherens junction organization	IMP IMP: Inferred from mutant phenotype	30639848	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	12649481	MGI
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	23144223	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12649481	MGI
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24658113	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	30639848	MGI
involved in corticospinal tract morphogenesis	IMP IMP: Inferred from mutant phenotype	9789074	MGI
involved in fasciculation of motor neuron axon	IMP IMP: Inferred from mutant phenotype	18403711	MGI
involved in fasciculation of sensory neuron axon	IMP IMP: Inferred from mutant phenotype	18403711	MGI
acts upstream of or within innervation	IMP IMP: Inferred from mutant phenotype	29518482	MGI
involved in motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	17785183	MGI
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	15537875	MGI
involved in negative regulation of long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	24658113	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	29518482	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	12761826	MGI
acts upstream of or within nephric duct morphogenesis	IGI IGI: Inferred from genetic interaction	25139858	MGI
involved in neuron projection fasciculation	IDA IDA: Inferred from direct assay	12761826	MGI
involved in neuron projection guidance	IDA IDA: Inferred from direct assay	12761826	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	10523642	MGI
involved in positive regulation of protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	24658113	MGI
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	17719550	MGI
involved in regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	18094260	MGI
involved in regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15537875	MGI
involved in regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	15537875	MGI
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	17143272	MGI
involved in regulation of modification of synaptic structure	IGI IGI: Inferred from genetic interaction	24658113	MGI
involved in synapse pruning	EXP EXP: Inferred from Experiment	12496762	MGI
involved in synapse pruning	IDA IDA: Inferred from direct assay	12496762	MGI
involved in synapse pruning	IMP IMP: Inferred from mutant phenotype	12496762	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18410519	MGI
is active in Schaffer collateral - CA1 synapse	IEP IEP: Inferred from expression pattern	18410519	MGI
located in axon	IDA IDA: Inferred from direct assay	17143272	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17143272	MGI
located in early endosome membrane	IDA IDA: Inferred from direct assay	17143272	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12496762	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12496762	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	18410519	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12496762	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17143272	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18410519	MGI
is active in postsynaptic membrane	IEP IEP: Inferred from expression pattern	18410519	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	18410519	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	18410519	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ephrin type-A receptor 4	tyrosine-protein kinase receptor MPK-3 tyrosine-protein kinase receptor SEK-1

Recombinant Epha4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72995	EphA4 Protein, Mouse (HEK293, Fc)	Q03137-1 (V20-T547)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78293	EphA4 Protein, Mouse (HEK293, His)	Q03137-1 (V20-T547)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0387	Rhynchophylline	Inhibitor	99.75%	Unkown
HY-P0177	123C4	Agonist	99.46%	Unkown
HY-P2264	KYL peptide	Inhibitor	99.65%	Unkown
HY-P11035	APY-d3	Inhibitor	99.18%	Unkown
HY-146375	UniPR505	Antagonist	99.68%	Unkown
HY-P10579	123B9	Agonist	99.67%	Unkown
HY-W078239	EPHA4 antagonist-1	Antagonist	95.61%	Unkown
HY-10654	EphB4-IN-2	Inhibitor	/	Unkown
HY-128391	AZ1136	Modulator	/	Unkown
HY-159174	EPHA2/A4/GAK-IN-1	Inhibitor	/	Unkown
HY-P11015	(123B9)2-Motif	Agonist	/	Unkown
HY-P11243	EphA4 agonist compound 23	Agonist	/	Unkown
HY-P11244	150D4	Agonist	/	Unkown
HY-RS04428	EPHA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17700	Epha4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24162	Epha4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991974	Anti-EPHA4 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epha4	NCBI	NCBI:2043