Bcl11a - B cell CLL/lymphoma 11A (zinc finger protein) Gene

Also Known as Evi9; Ctip1; Evi9a; Evi9b; Evi9c; BCL-11A; mKIAA1809; 2810047E18Rik; D930021L15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14025

Summary

Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Acts upstream of or within B cell differentiation; T cell differentiation; and negative regulation of gene expression. Located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BAF chromatin remodeling complex subunit BCL11A). [provided by Alliance of Genome Resources, Apr 2022]

Bcl11a Products (4)

mRNA Protein Name
NM_001159289.1 NP_001152761.1 B-cell lymphoma/leukemia 11A isoform 2
NM_001159290.1 NP_001152762.1 B-cell lymphoma/leukemia 11A isoform 3
NM_001242934.1 NP_001229863.1 B-cell lymphoma/leukemia 11A isoform 4
NM_016707.3 NP_057916.1 B-cell lymphoma/leukemia 11A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18681895 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10744719 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12717432 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
12717432 MGI
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
19657335 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19657335 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
29606353 MGI
involved in protein sumoylation IMP
IMP: Inferred from mutant phenotype
18681895 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
23644491 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
18681895 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10744719 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell lymphoma/leukemia 11A

  • B-cell CLL/lymphoma 11A

  • COUP-TF interacting protein 1

  • EVI-9

  • ecotropic viral integration site 9 protein

  • myeloid leukemia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152775 RK-701 Inhibitor 98.01% Unkown
HY-RS01413 BCL11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20529 Bcl11a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27038 Bcl11a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl11a NCBI NCBI:53335