Fech - ferrochelatase Gene

Also Known as Fcl; fch

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14151

Summary

Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Acts upstream of or within several processes, including porphyrin-containing compound metabolic process; regulation of cellular macromolecule biosynthetic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]

Fech Products (2)

mRNA Protein Name
NM_001348055.2 NP_001334984.1 ferrochelatase, mitochondrial isoform 2
NM_007998.8 NP_032024.2 ferrochelatase, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ferrochelatase activity IDA
IDA: Inferred from direct assay
2246229 MGI
enables ferrochelatase activity IMP
IMP: Inferred from mutant phenotype
8325637 MGI
enables heme binding IDA
IDA: Inferred from direct assay
16503645 MGI
enables iron ion binding IDA
IDA: Inferred from direct assay
14981080 MGI
enables iron-responsive element binding IDA
IDA: Inferred from direct assay
7575558 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20427704 MGI
enables tetrapyrrole binding IDA
IDA: Inferred from direct assay
14981080 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
11160364 MGI
acts upstream of or within detection of UV IMP
IMP: Inferred from mutant phenotype
12149233 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
1939658 MGI
involved in heme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
15677551 MGI
involved in heme B biosynthetic process IMP
IMP: Inferred from mutant phenotype
15677551 MGI
involved in heme O biosynthetic process IMP
IMP: Inferred from mutant phenotype
15677551 MGI
acts upstream of or within heme biosynthetic process IDA
IDA: Inferred from direct assay
15496139 MGI
acts upstream of or within heme biosynthetic process IMP
IMP: Inferred from mutant phenotype
8611576 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
17003376 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: Inferred from mutant phenotype
12149233 MGI
acts upstream of or within protoporphyrinogen IX metabolic process IGI
IGI: Inferred from genetic interaction
15931390 MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme IGI
IGI: Inferred from genetic interaction
15931390 MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme IMP
IMP: Inferred from mutant phenotype
15931390 MGI
acts upstream of or within regulation of hemoglobin biosynthetic process IGI
IGI: Inferred from genetic interaction
15931390 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
1939658 MGI
acts upstream of or within very-low-density lipoprotein particle assembly IMP
IMP: Inferred from mutant phenotype
11160364 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27599036 MGI
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
30366982 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ferrochelatase, mitochondrial

  • heme synthase

  • heme synthetase

  • protoheme ferro-lyase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114758 Pyridoxal isonicotinoyl hydrazone Inhibitor 99.96% Unkown
HY-RS04857 FECH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20276 Fech Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26784 Fech Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fech NCBI NCBI:2235