Fgfr2 - fibroblast growth factor receptor 2 Gene

Also Known as Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14183

About Fgfr2

Chromosome 7: 129,764,181-132,725,079 reverse strand.GRCm39:CM001000.3

This gene has 27 transcripts (splice variants), 219 orthologues, 53 paralogues and is associated with 278 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 15.2), lung adult (RPKM 13.2) and 25 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity. Involved in Fibroblast Growth Factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ Cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products (3)

mRNA	Protein	Name
NM_010207.2	NP_034337.2	fibroblast growth factor receptor 2 isoform IIIc
NM_201601.2	NP_963895.2	fibroblast growth factor receptor 2 isoform IIIb
NM_001347638.1	NP_001334567.1	fibroblast growth factor receptor 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	9435295	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8393815	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	17951031	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	12756187	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	10518547	MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11731698	MGI
acts upstream of or within branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	17951031	MGI
acts upstream of or within bud elongation involved in lung branching	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of cell division	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	15509736	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within coronal suture morphogenesis	IMP IMP: Inferred from mutant phenotype	19389359	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	15234214	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within embryonic organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within endodermal digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	21550054	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9435295	MGI
involved in fibroblast growth factor receptor signaling pathway involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	20345253	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IMP IMP: Inferred from mutant phenotype	16720875	MGI
involved in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	IMP IMP: Inferred from mutant phenotype	20345253	MGI
involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
involved in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	20345253	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	17202188	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10934262	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	10821755	MGI
acts upstream of or within lateral sprouting from an epithelium	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within lens fiber cell development	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within lens fiber cell development	IMP IMP: Inferred from mutant phenotype	23136392	MGI
acts upstream of or within limb bud formation	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10518547	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within lung-associated mesenchyme development	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of or within lung-associated mesenchyme development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within mammary gland bud formation	IMP IMP: Inferred from mutant phenotype	11782400	MGI
acts upstream of or within membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
acts upstream of or within mesenchymal cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within mesenchymal cell proliferation involved in lung development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	17418794	MGI
acts upstream of or within odontogenesis	IMP IMP: Inferred from mutant phenotype	17951031	MGI
involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within otic vesicle formation	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18187602	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21492869	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16989802	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of urothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within prostate epithelial cord elongation	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18184727	MGI
involved in pyramidal neuron development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within regulation of morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	17202188	MGI
acts upstream of or within regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	12756187	MGI
acts upstream of or within regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	17418794	MGI
acts upstream of or within ureteric bud development	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of urothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
involved in ventricular zone neuroblast division	IMP IMP: Inferred from mutant phenotype	20410112	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in excitatory synapse	IMP IMP: Inferred from mutant phenotype	20410112	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15229180	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr2 Protein Structure

IgI_2_FGFR

IgI_3_FGFR2

PTKc_FGFR2

0
200
400
600
800
840 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 2	keratinocyte growth factor receptor

Recombinant Fgfr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76339	FGFR-2 Protein, Mouse (HEK293, Fc)	E9Q5C3 (R22-E263)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76340	FGFR-2 Protein, Mouse (HEK293, His)	E9Q5C3/AAA39377.1 (R22-E263)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77661	FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His)	P21803-2 (P39-E263)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163705	BR-cpd7	Degrader	98.01%	Unkown
HY-165298	DGY-09-192	Degrader	99.50%	Unkown
HY-181752	FGFR3-IN-12	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-184598	CYB-5067	Degrader	/	Unkown
HY-184322	LC-MG-10	Degrader	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown
HY-184321	LC-MG-5	Degrader	/	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991584	HuGAL-FR21	Inhibitor	97.80%	Unkown
HY-P991583	GP369	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr2	NCBI	NCBI:2263