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MIB2 - MIB E3 ubiquitin protein ligase 2 Gene

Also Known as ZZZ5; ZZANK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 142678

About MIB2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,613,731-1,630,605 (from NCBI)

This gene has 32 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin protein Ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]

MIB2 Products (5)

mRNA	Protein	Name
NM_001170686.4	NP_001164157.3	E3 ubiquitin-protein ligase MIB2 isoform 2
NM_001170687.4	NP_001164158.3	E3 ubiquitin-protein ligase MIB2 isoform 1
NM_001170688.2	NP_001164159.2	E3 ubiquitin-protein ligase MIB2 isoform 4
NM_001170689.2	NP_001164160.1	E3 ubiquitin-protein ligase MIB2 isoform 5
NM_080875.5	NP_543151.4	E3 ubiquitin-protein ligase MIB2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables ubiquitin-protein transferase activity	EXP EXP: Inferred from Experiment	31366726	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIB2 Protein Structure

MIB_HERC2

Ank_5

Ank_2

Ank_4

Ank_2

zf-C3HC4_3

0
200
400
600
800
1000
1070 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase MIB2	RING-type E3 ubiquitin transferase MIB2

MIB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MIB2	Q96AX9	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Autosomal Recessive Alport Syndrome	Alport Syndrome, Recessive Type Alport Syndrome, Autosomal Recessive Alport Syndrome Autosomal Recessive Alport Syndrome Recessive Type Nephropathy And Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08423	MIB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIB2	MGD	MGI:2679684
Rattus norvegicus	MIB2	RGD	RGD:1359469
Macaca mulatta	MIB2	VGNC	VGNC:74627
Felis catus	MIB2	VGNC	VGNC:80282
Canis familiaris	MIB2	VGNC	VGNC:43218
Bos taurus	MIB2	VGNC	VGNC:31456
Others	MIB2	NCBI