Fzd4 - frizzled class receptor 4 Gene

Also Known as Fz4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14366

Summary

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (Frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Fzd4 Products (1)

mRNA Protein Name
NM_008055.4 NP_032081.3 frizzled-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IPI
IPI: Inferred from physical interaction
16163358 MGI
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
12490564 MGI
enables cytokine binding IPI
IPI: Inferred from physical interaction
15035989 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15195140 MGI
enables signaling receptor activity IGI
IGI: Inferred from genetic interaction
25424568 MGI
Biological Process GO Annotation Evidence References Source
involved in Norrin signaling pathway IDA
IDA: Inferred from direct assay
15035989 MGI
involved in Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
25424568 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
27823583 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
27823583 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
19837032 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16115200 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19001373 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
25414188 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in cerebellum vasculature morphogenesis IMP
IMP: Inferred from mutant phenotype
15035989 MGI
acts upstream of or within endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
23217714 MGI
acts upstream of or within establishment of blood-brain barrier IGI
IGI: Inferred from genetic interaction
30478038 MGI
acts upstream of or within establishment of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
23217714 MGI
involved in extracellular matrix-cell signaling IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within locomotion involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
11425903 MGI
acts upstream of or within luteinization IMP
IMP: Inferred from mutant phenotype
16093361 MGI
involved in negative regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
18156211 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within positive regulation of JUN kinase activity IGI
IGI: Inferred from genetic interaction
15195140 MGI
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 MGI
acts upstream of or within progesterone secretion IMP
IMP: Inferred from mutant phenotype
16093361 MGI
acts upstream of or within regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16093361 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
25414188 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: Inferred from mutant phenotype
23217714 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IGI
IGI: Inferred from genetic interaction
19837032 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
19837032 MGI
involved in retinal blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15035989 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
11425903 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18156211 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16093361 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
15195140 MGI
located in dendrite IMP
IMP: Inferred from mutant phenotype
25424568 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16501258 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15035989 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
18156211 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16501258 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-4

  • frizzled homolog 4

  • fz-4

  • mFz4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117163 FzM1.8 Agonist 98.93% Unkown
HY-116553 FzM1 Inhibitor 98.72% Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-RS05180 FZD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17330 Fzd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23785 Fzd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992126 Remigromig Inhibitor 95.25% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd4 NCBI NCBI:8322