Fzd8 - frizzled class receptor 8 Gene

Also Known as Fz8

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14370

Summary

Enables several functions, including PDZ domain binding activity; Wnt-activated receptor activity; and Wnt-protein binding activity. Involved in Wnt signaling pathway. Acts upstream of or within several processes, including T cell differentiation in thymus; angiogenesis; and positive regulation of JUN kinase activity. Located in plasma membrane. Part of Wnt-Frizzled-LRP5/6 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FZD8 (Frizzled class receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Fzd8 Products (1)

mRNA	Protein	Name
NM_008058.2	NP_032084.2	frizzled-8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	11520064	MGI
enables Wnt receptor activity	IPI IPI: Inferred from physical interaction	15454084	MGI
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	11357136	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11029007	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11029007	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	11265645	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	19129494	MGI
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	11357136	MGI
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	19129494	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16543246	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16115200	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11265645	MGI
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	15195140	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15143170	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Wnt-Frizzled-LRP5/6 complex	IDA IDA: Inferred from direct assay	20093360	MGI
part of Wnt-Frizzled-LRP5/6 complex	IPI IPI: Inferred from physical interaction	11029007	MGI
is active in neuronal dense core vesicle	EXP EXP: Inferred from Experiment	21321602	MGI
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	21321602	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15035989	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
frizzled-8	frizzled homolog 8 fz-8

Fzd8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Fzd8	Q61091	Igfbp4	Mus musculus	P47879	Anti Tag CoIP	18528331
Intra	Fzd8	Q61091	Wnt3a	Mus musculus	P27467	Pull Down	31036956
Intra	Fzd8	Q61091	Wnt3a	Mus musculus	P27467	BLI	23791946
Intra	Fzd8	Q61091	Wnt3a	Mus musculus	P27467	Pull Down	22575959
Intra	Fzd8	Q61091	Wnt3a	Mus musculus	P27467	Anti Tag CoIP	18528331
Intra	Fzd8	Q61091	Gopc	Mus musculus	Q8BH60	Anti Tag CoIP	11520064
Intra	Fzd8	Q61091	Gopc	Mus musculus	Q8BH60	Pull Down	11520064
Cross	Fzd8	Q61091	WNT3	Homo sapiens	P56703	X-Ray Diffraction	31036956
Cross	Fzd8	Q61091	WNT3	Homo sapiens	P56703	GMS	31036956
Cross	Fzd8	Q61091	LRP6	Homo sapiens	O75581	Pull Down	11029007
Cross	Fzd8	Q61091	wnt8	Crosspus laevis	P28026	X-Ray Diffraction	22653731
Cross	Fzd8	Q61091	wnt8	Crosspus laevis	P28026	Chromatography	22653731
Cross	Fzd8	Q61091	wnt8	Crosspus laevis	P28026	SPR	22653731

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99667	Ipafricept	Inhibitor	99.80%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05184	FZD8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18477	Fzd8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24958	Fzd8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd8	NCBI	NCBI:8325