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BCDIN3D - BCDIN3 domain containing RNA methyltransferase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 144233

About BCDIN3D

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,836,043-49,843,106 (from NCBI)

This gene has 2 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 3.3), lymph node (RPKM 3.0) and 25 other tissues.

Summary

This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast Cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast Cancer. The encoded protein is thought to promote the cellular invasion of breast Cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

BCDIN3D Products (1)

mRNA	Protein	Name
NM_181708.3	NP_859059.1	RNA 5'-monophosphate methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables O-methyltransferase activity	EXP EXP: Inferred from Experiment	23063121	GOA
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	23063121	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	33664453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables small RNA 2'-O-methyltransferase activity	IDA IDA: Inferred from direct assay	23063121	GOA
enables tRNA methyltransferase activity	IDA IDA: Inferred from direct assay	28119416	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA methylation	IDA IDA: Inferred from direct assay	33664453	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: Inferred from direct assay	23063121	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	33664453	GOA
involved in tRNA methylation	IDA IDA: Inferred from direct assay	28119416	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23063121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCDIN3D Protein Structure

Bin3

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
RNA 5'-monophosphate methyltransferase	BCDIN3 domain containing RNA methyltransfease

BCDIN3D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCDIN3D	Q7Z5W3	ZFP2	Homo sapiens	Q6ZN57	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Essential Hypertension	Accelerated Essential Hypertension
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111367	MS2734	Inhibitor	/	Unkown
HY-RS01405	BCDIN3D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCDIN3D	VGNC	VGNC:26442
Mus musculus	BCDIN3D	MGD	MGI:1922534
Canis familiaris	BCDIN3D	VGNC	VGNC:38404
Macaca mulatta	BCDIN3D	VGNC	VGNC:70137
Rattus norvegicus	BCDIN3D	RGD	RGD:1306433
Felis catus	BCDIN3D	VGNC	VGNC:60081
Others	BCDIN3D	NCBI