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144363

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By Targets:	Apoptosis (2) Integrin (1) Reference Standards (1) Thrombin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100738

Ubiquitin Isopeptidase Inhibitor I, G5 5+ Cited Publications NSC144303	Apoptosis	Cancer
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC₅₀ values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

HY-19175

FK 633 FR-144633	Thrombin Integrin	Cardiovascular Disease
FK 633 (FR-144633) is a fibrinogen inhibitor and peptide mimetic GPⅡbⅡa receptor antagonist. FK 633 has anti-platelet and anti-thrombotic effects. FK 633 inhibits ADP-, collagen-, thrombin-, and PAF-induced platelet aggregation with IC₅₀ values of 103, 87, 98, and 239 nM, respectively .

HY-100738R

Ubiquitin Isopeptidase Inhibitor I, G5 (Standard) NSC144303 (Standard)	Apoptosis Reference Standards	Cancer
Ubiquitin Isopeptidase Inhibitor I, G5 (Standard) is the analytical standard of Ubiquitin Isopeptidase Inhibitor I, G5 (HY-100738). This product is intended for research and analytical applications. Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704877

	SHP-2 Protein, Human (N-His) protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;	Human	E. coli

HY-P700618

	SHP-2 Protein, Human (T253M, Q257L, His) 1 Publications Verification protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;	Human	E. coli
	The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L mutation.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) FC (2) ELISA (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal Antibody (1)
Modification:	Unmodified (1)

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HY-P84492

	SHP2 Antibody (YA4189) CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; MGC14433	IHC-P, ICC/IF, FC, ELISA	Human
	SHP2 Antibody (YA4189) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SHP2.

HY-P84492A

	SHP2 Antibody (YA4189)(PBS only) CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; MGC14433	IHC-P, ICC/IF, FC, ELISA	Human
	SHP2 Antibody (YA4189) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SHP2.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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