Gh - growth hormone Gene
Also Known as Gh1; Ghb1
Species: Mus musculus
Gene Type: protein coding
Gene ID: 14599
Summary
Enables growth hormone receptor binding activity. Acts upstream of or within cellular response to Insulin stimulus; regulation of growth; and response to food. Located in several cellular components, including extracellular space; secretory granule; and trans-Golgi network. Is expressed in brain; early conceptus; gut; hemolymphoid system; and male reproductive system. Used to study isolated growth hormone deficiency type II. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1). [provided by Alliance of Genome Resources, Apr 2022]
Gh Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_008117.3 | NP_032143.1 | somatotropin precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables growth hormone receptor binding |
IPI
IPI: Inferred from physical interaction
|
10556780 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within cellular response to insulin stimulus |
IDA
IDA: Inferred from direct assay
|
16513828 | MGI |
| acts upstream of or within positive regulation of multicellular organism growth |
IGI
IGI: Inferred from genetic interaction
|
16467156 | MGI |
| acts upstream of or within response to food |
IDA
IDA: Inferred from direct assay
|
16513828 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
7664670 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
9144201 | MGI |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
9144201 | MGI |
| located in secretory granule |
IDA
IDA: Inferred from direct assay
|
1329576 | MGI |
| located in trans-Golgi network |
IDA
IDA: Inferred from direct assay
|
9144201 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
somatotropin |
|
Recombinant Gh Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70261 | GH/Somatotropin Protein, Mouse | P06880 (F27-F216) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(8)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-14734 | Anamorelin | Agonist | 99.94% | Unkown |
| HY-16381 | Pasireotide | Agonist | 99.94% | Yes |
| HY-14734A | Anamorelin hydrochloride | Agonist | 99.59% | Unkown |
| HY-16381A | Pasireotide acetate | Agonist | 99.92% | Unkown |
| HY-14820A | Macimorelin acetate | Agonist | 99.34% | Yes |
| HY-108905 | Mecasermin | / | Unkown | |
| HY-14820 | Macimorelin | Agonist | / | Unkown |
| HY-14734B | Anamorelin Fumarate | Agonist | / | Unkown |
Clinical Phase
Bioactive Molecules
(4)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-50844 | Ibutamoren Mesylate | Agonist | 99.86% | Phase 2 |
| HY-P0024 | Veldoreotide | Activator | / | Phase 2 |
| HY-153485 | Cimdelirsen | Inhibitor | / | Phase 2 |
| HY-153485A | Cimdelirsen sodium | Inhibitor | / | Phase 2 |
Bioactive MoleculesInhibitory Antibodies
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-P99900 | Sevirumab | Inhibitor | 99.9% | Phase 3 |
Pre-clinical Phase
Bioactive Molecules
(64)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-13913 | NS-398 | Inhibitor | 99.71% | Unkown |
| HY-P5645 | LEAP-2 | 97.75% | Unkown | |
| HY-P2875 | Hemicellulase | / | Unkown | |
| HY-P0089A | Human growth hormone-releasing factor TFA | Activator | 99.49% | Unkown |
| HY-N1939 | Icariside I | 98.76% | Unkown | |
| HY-P1777 | IGF-I (24-41) | 99.84% | Unkown | |
| HY-101422 | GAL-021 | Inhibitor | 99.93% | Unkown |
| HY-139431 | NAG-thiazoline | Inhibitor | ≥95.0% | Unkown |
| HY-P2869A | β1-3 Galactosidase | / | Unkown | |
| HY-D1599 | Rhodamine 6G hydrazide | 98.25% | Unkown | |
| HY-P0024A | Veldoreotide TFA | Agonist | 98.97% | Unkown |
| HY-P5189A | His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA | 99.94% | Unkown | |
| HY-P1139 | Cortistatin-8 | Antagonist | 99.56% | Unkown |
| HY-P1155 | GRF (1-29) amide (rat) | Inducer | 99.80% | Unkown |
| HY-P2866 | β-N-Acetylhexosaminidase, Streptococcus pneumoniae | Inducer | 96.00% | Unkown |
| HY-117931 | NS004 | Activator | 99.67% | Unkown |
| HY-149902 | USP8-IN-3 | Inhibitor | 98.37% | Unkown |
| HY-50760 | L-692585 | Agonist | 98.94% | Unkown |
| HY-D1515 | FM1-84 | 98.92% | Unkown | |
| HY-P0089 | Human growth hormone-releasing factor | Activator | 98.63% | Unkown |
| HY-113906A | (αR,8aS)-GSK1614343 | Control | 99.72% | Unkown |
| HY-P4750 | Acetyl-(D-Arg2)-GRF (1-29) amide (human) | Antagonist | 99.67% | Unkown |
| HY-W011410 | 4-Nitrophenyl β-D-mannopyranoside | Substrate | 98.50% | Unkown |
| HY-107678 | SEN12333 | Agonist | 98.45% | Unkown |
| HY-10957 | L-692429 | Agonist | 99.90% | Unkown |
| HY-115661 | Bisdionin C | Inhibitor | 98.97% | Unkown |
| HY-121580 | Tabimorelin | Inhibitor | 98.11% | Unkown |
| HY-142110 | LY 78335 | Inhibitor | 99.19% | Unkown |
| HY-E70033 | D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) | / | Unkown | |
| HY-E70107 | Cellobiohydrolase I, Trichoderma longibrachiatum | / | Unkown | |
| HY-P4405 | (D-Ala2)-GRF (1-29) amide (human) | Agonist | 98.83% | Unkown |
| HY-101422A | GAL-021 sulfate | Inhibitor | / | Unkown |
| HY-103540 | Tabimorelin hemifumarate | Inhibitor | / | Unkown |
| HY-108241A | Galacto-PUGNAc | Inhibitor | / | Unkown |
| HY-110161 | sst2 Receptor agonist-1 | Agonist | / | Unkown |
| HY-117584 | L-163255 free base | / | Unkown | |
| HY-118995 | L-739943 | Activator | / | Unkown |
| HY-119125 | BMS-317180 | Agonist | / | Unkown |
| HY-125673 | AC-178335 | / | Unkown | |
| HY-130070 | QO-40 | Activator | 98.77% | Unkown |
| HY-147666 | α-Synuclein inhibitor 4 | Inhibitor | / | Unkown |
| HY-175053 | Pasireotide (aspartate) TFA | / | Unkown | |
| HY-E70029A | Alpha-1,6-fucosidase C | / | Unkown | |
| HY-E70316 | Endo-chitosanase | / | Unkown | |
| HY-E71264 | β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron | / | Unkown | |
| HY-P1773 | IGF-I (30-41) | / | Unkown | |
| HY-P1773A | IGF-I (30-41) TFA | / | Unkown | |
| HY-P1777A | IGF-I (24-41) TFA | / | Unkown | |
| HY-P2802B | α-Glucosidase, rice | / | Unkown | |
| HY-P3056 | GHRF, ovine | / | Unkown | |
| HY-P3169 | a-Helical Corticotropin Releasing Factor (9-41) | Antagonist | / | Unkown |
| HY-P3595 | GHRF, porcine | Activator | / | Unkown |
| HY-P3607 | GHRF, bovine | Activator | / | Unkown |
| HY-RS05399 | GGH Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS05408 | GH1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS05409 | GH2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS14459 | TGM2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-10957A | L-692429 hydrochloride | Agonist | / | Unkown |
| HY-116959 | SM-130686 | / | Unkown | |
| HY-119997 | Disulergine | Agonist | / | Unkown |
| HY-180210 | Ghrelin receptor full agonist-3 | Agonist | / | Unkown |
| HY-E70111 | Endo-1,5-α-arabinanase | / | Unkown | |
| HY-RS24406 | Gh1 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-W774937 | Cycloprothrin | / | Unkown |
Bioactive MoleculesInhibitory Antibodies
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P991741 | Anti-HCMV gB Antibody (SM5-1) | / | Unkown |
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