Glul - glutamate-ammonia ligase (glutamine synthetase) Gene

Also Known as GS; Glns

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14645

Summary

Predicted to enable several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in regulation of endothelial cell migration and regulation of sprouting angiogenesis. Acts upstream of or within cellular response to starvation and response to glucose. Located in cell body; cytoplasm; and glial cell projection. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Glul Products (1)

mRNA Protein Name
NM_008131.5 NP_032157.2 glutamine synthetase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16323283 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to starvation IEP
IEP: Inferred from expression pattern
23260145 MGI
involved in regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
30158707 MGI
involved in regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
30158707 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
17854388 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
23386608 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12923239 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
23386608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamine synthetase

  • glutamate decarboxylase

  • glutamate-ammonia ligase (glutamine synthase)

  • palmitoyltransferase GLUL

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05509 GLUL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17491 Glul Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23948 Glul Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glul NCBI NCBI:2752