Gstp1 - glutathione S-transferase, pi 1 Gene

Also Known as GstpiB

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14870

Summary

Enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of intracellular signal transduction; and negative regulation of macromolecule metabolic process. Acts upstream of or within glutathione metabolic process. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic Cancer (multiple); reproductive organ Cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (Glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]

Gstp1 Products (1)

mRNA Protein Name
NM_013541.1 NP_038569.1 glutathione S-transferase P 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase binding IPI
IPI: Inferred from physical interaction
11279197 MGI
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
7982937 MGI
enables kinase regulator activity IMP
IMP: Inferred from mutant phenotype
12646564 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
16023107 MGI
involved in common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
11408560 MGI
acts upstream of or within glutathione metabolic process IDA
IDA: Inferred from direct assay
7982937 MGI
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16023107 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16023107 MGI
involved in negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
11408560 MGI
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
18962899 MGI
involved in negative regulation of leukocyte proliferation IMP
IMP: Inferred from mutant phenotype
11408560 MGI
involved in negative regulation of monocyte chemotactic protein-1 production IDA
IDA: Inferred from direct assay
18962899 MGI
involved in negative regulation of nitric-oxide synthase biosynthetic process IDA
IDA: Inferred from direct assay
16023107 MGI
involved in negative regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
16023107 MGI
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
16023107 MGI
involved in positive regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
11408560 MGI
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
10945608 MGI
involved in regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
10945608 MGI
involved in response to reactive oxygen species IDA
IDA: Inferred from direct assay
10945608 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15100242 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
11279197 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione S-transferase P 1

  • GST YF-YF

  • GST class-pi

  • GST-piB

  • Gst p-1

  • gst P1

  • preadipocyte growth factor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16123 Canfosfamide hydrochloride Chemical / Phase 3
HY-13634 Ezatiostat hydrochloride / Phase 2
HY-13634A Ezatiostat 99.82% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135318 NBDHEX 99.22% Unkown
HY-115673 LAS17 Inhibitor 97.46% Unkown
HY-13634B TLK117 Inhibitor 99.86% Unkown
HY-112534 GSTO-IN-2 Inhibitor 98.0% Unkown
HY-P2961 Glutathione S-transferase / Unkown
HY-145413 BRD2889 Inhibitor / Unkown
HY-132913 Cyclopropenone probe 1 / Unkown
HY-157426 PROTAC BRD4 Degrader-50 Degrader / Unkown
HY-160455 GSTP1-1 inhibitor 1 / Unkown
HY-169058 GSTP1-1 inhibitor 2 Inhibitor / Unkown
HY-178372 GSTO1-IN-4 Inhibitor / Unkown
HY-179217 GSTP1/M2-IN-1 / Unkown
HY-182059 GSTP1-IN-1 / Unkown
HY-RS05886 GSTP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W615446 GSTO1-IN-3 Inhibitor / Unkown
HY-167632 meso-Zeaxanthin 93.09% Unkown
HY-N11778 Bequinostatin C / Unkown
HY-RS16643 Gstp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23077 Gstp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gstp1 NCBI NCBI:2950