Cfb - complement factor B Gene

Also Known as Bf; C2; Fb; H2-Bf

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14962

Summary

Predicted to enable serine-type endopeptidase activity. Acts upstream of or within complement activation, alternative pathway. Predicted to be located in extracellular region. Is expressed in embryo and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (Complement Factor B). [provided by Alliance of Genome Resources, Apr 2022]

Cfb Products (3)

mRNA Protein Name
NM_001142706.2 NP_001136178.1 complement factor B isoform 2 precursor
NM_001402875.1 NP_001389804.1 complement factor B isoform 3 precursor
NM_008198.3 NP_032224.2 complement factor B isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
27564415 MGI
acts upstream of or within complement activation, alternative pathway IMP
IMP: Inferred from mutant phenotype
9238044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor B

  • C3/C5 convertase

  • Factor B

  • alternative-complement pathway C3/C5 convertase

  • complement component 2 (within H-2S)

  • histocompatibility 2, complement component factor B

  • properdin

Recombinant Cfb Proteins

Cat. No. Product Name Accession Purity
HY-P72137 Complement Factor B/CFB Protein, Mouse (His) P04186 (T23-L761) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148370A Sefaxersen sodium Inhibitor 99.46% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148370 Sefaxersen Inhibitor 99.46% Unkown
HY-174913 Factor B-IN-5 Inhibitor / Unkown
HY-RS02557 CFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17438 Cfb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23894 Cfb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfb NCBI NCBI:629