COMMD7 - COMM domain containing 7 Gene

Also Known as C20orf92; dJ1085F17.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149951

About COMMD7

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,702,699-32,743,467 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 17.9), placenta (RPKM 13.5) and 25 other tissues.

Summary

Enables NF-kappaB binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription, DNA-templated; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

COMMD7 Products (2)

mRNA Protein Name
NM_001099339.2 NP_001092809.1 COMM domain-containing protein 7 isoform 2
NM_053041.3 NP_444269.2 COMM domain-containing protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IDA
IDA: Inferred from direct assay
15799966 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15799966 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15799966 GOA
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
15799966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD7 Protein Structure

COMM_domain

COMM_domain: COMM domain (20 - 198)

  • 0
  • 100
  • 200 a.a.
Protein Preferred Names Protein Names

COMM domain-containing protein 7

COMMD7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COMMD7 Q86VX2 CCDC93 Homo sapiens Q567U6
Pull Down
25355947
Intra
COMMD7 Q86VX2 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
37172566
Intra
COMMD7 Q86VX2 COMMD1 Homo sapiens Q8N668
Anti Tag CoIP
37172566
Intra
COMMD7 Q86VX2 CCDC22 Homo sapiens O60826
Pull Down
23563313
Intra
COMMD7 Q86VX2 CCDC22 Homo sapiens O60826
Anti Tag CoIP
37172566
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03014 COMMD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus COMMD7 VGNC VGNC:27587
Canis familiaris COMMD7 VGNC VGNC:39497
Rattus norvegicus COMMD7 RGD RGD:1307786
Macaca mulatta COMMD7 VGNC VGNC:81182
Mus musculus COMMD7 MGD MGI:1914197
Others COMMD7 NCBI