HORMAD2 - HORMA domain containing 2 Gene

Also Known as CT46.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150280

About HORMAD2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,077,732-30,207,456 (from NCBI)

This gene has 4 transcripts (splice variants), 124 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 6.8).

Summary

Predicted to be involved in meiotic sister chromatid cohesion. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HORMAD2 Products (3)

mRNA Protein Name
NM_001329457.2 NP_001316386.1 HORMA domain-containing protein 2 isoform a
NM_001329458.2 NP_001316387.1 HORMA domain-containing protein 2 isoform b
NM_152510.4 NP_689723.1 HORMA domain-containing protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HORMAD2 Protein Structure

HORMA

HORMA: HORMA domain (27 - 228)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

HORMA domain-containing protein 2

HORMAD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HORMAD2 Q8N7B1 NSD2 Homo sapiens O96028
Y2H Prey Pooling
32296183
Intra
HORMAD2 Q8N7B1 NSD2 Homo sapiens O96028
Y2H Array
32296183
Intra
HORMAD2 Q8N7B1 PDLIM1 Homo sapiens O00151
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autoimmune Glomerulonephritis
Nephrotic Syndrome, Type 7

  • Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7

  • NPHS7

  • Nephrotic Syndrome Type 7

  • Ig-Mediated Membranoproliferative Glomerulonephritis

  • Ig-Mediated Mpgn

  • Immunoglobulin-Mediated Mpgn

  • Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical 7

  • Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome With Dgke Deficiency

  • Hus With Dgke Deficiency

  • Hemolytic Uremic Syndrome Atypical 7

  • AHUS7

  • Nephrotic Syndrome 7

  • Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
Nephronophthisis 3

  • NPHP3

  • Nph3

  • Adolescent Nephronophthisis

  • Nephronophthisis, Type 3
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06292 HORMAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HORMAD2 VGNC VGNC:84915
Mus musculus HORMAD2 MGD MGI:1923078
Bos taurus HORMAD2 VGNC VGNC:53905
Felis catus HORMAD2 VGNC VGNC:80442
Rattus norvegicus HORMAD2 RGD RGD:1565447
Canis familiaris HORMAD2 VGNC VGNC:52934
Others HORMAD2 NCBI