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DPPA2 - developmental pluripotency associated 2 Gene

Also Known as CT100; PESCRG1; ECAT15-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151871

About DPPA2

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:109,293,788-109,316,517 (from NCBI)

This gene has 1 transcript (splice variant), 131 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 2.2).

Summary

Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including lung-associated mesenchyme development; positive regulation of stem cell proliferation; and regulation of histone methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DPPA2 Products (1)

mRNA	Protein	Name
NM_138815.4	NP_620170.3	developmental pluripotency-associated protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPPA2 Protein Structure

Dppa2_A

DCR

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
developmental pluripotency-associated protein 2	cancer/testis antigen 100

DPPA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DPPA2	Q7Z7J5	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	DPPA2	Q7Z7J5	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	DPPA2	Q7Z7J5	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	DPPA2	Q7Z7J5	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	DPPA2	Q7Z7J5	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	DPPA2	Q7Z7J5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DPPA2	Q7Z7J5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DPPA2	Q7Z7J5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DPPA2	Q7Z7J5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	DPPA2	Q7Z7J5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	DPPA2	Q7Z7J5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	DPPA2	Q7Z7J5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	DPPA2	Q7Z7J5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	DPPA2	Q7Z7J5	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Astigmatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03970	DPPA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPPA2	MGD	MGI:2157523
Felis catus	DPPA2	VGNC	VGNC:61608
Others	DPPA2	NCBI