Hbegf - heparin-binding EGF-like growth factor Gene

Also Known as Dtr; Dts; Hegfl

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15200

Summary

Enables epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hbegf Products (1)

mRNA	Protein	Name
NM_010415.2	NP_034545.1	proheparin-binding EGF-like growth factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	1840698	MGI
enables growth factor activity	IDA IDA: Inferred from direct assay	1840698	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	1840698	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	12621152	MGI
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	12621152	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	12621152	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IMP IMP: Inferred from mutant phenotype	12621152	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERBB2-EGFR signaling pathway	IMP IMP: Inferred from mutant phenotype	21946538	MGI
involved in ERBB2-ERBB4 signaling pathway	IMP IMP: Inferred from mutant phenotype	12621152	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	15923649	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	12621152	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8702723	MGI
involved in positive regulation of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	15923649	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8702723	MGI
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	1840698	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	12621152	MGI
involved in wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	15923649	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	12621152	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9857183	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9857183	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
proheparin-binding EGF-like growth factor	diphtheria toxin receptor heparin binding epidermal growth factor-like growth factor

Recombinant Hbegf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7194	HB-EGF Protein, Mouse	Q06186 (D63-L148)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990609	KHK-2866		98.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180536	HB-EGF-IN-1	Inhibitor	/	Unkown
HY-D2004	ATTO 488 streptavidin		/	Unkown
HY-RS06029	HBEGF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174671	Human HBEGF mRNA		/	Unkown
HY-RS17058	Hbegf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23502	Hbegf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hbegf	NCBI	NCBI:1839