Hpse - heparanase Gene

Mus musculus

Also known as Hpa; HSE1; Hpr1

Gene ID: 15442 | Gene type: protein coding

About Hpse

Summary

This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]

Hpse Products(1)

mRNA	Protein	Name
NM_152803.5	NP_690016.1	heparanase preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparanase activity	IDA IDA: Inferred from direct assay	12460766	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis involved in wound healing	IDA IDA: Inferred from direct assay	15793281	MGI
involved in establishment of endothelial barrier	IDA IDA: Inferred from direct assay	27026367	MGI
involved in heparan sulfate proteoglycan catabolic process	IDA IDA: Inferred from direct assay	12460766	MGI
involved in heparin metabolic process	IDA IDA: Inferred from direct assay	27026367	MGI
involved in heparin metabolic process	IMP IMP: Inferred from mutant phenotype	27026367	MGI
involved in positive regulation of hair follicle development	IDA IDA: Inferred from direct assay	15793281	MGI
involved in positive regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	18589009	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	17689495	MGI
involved in protein transmembrane transport	IMP IMP: Inferred from mutant phenotype	27026367	MGI
involved in response to antibiotic	IDA IDA: Inferred from direct assay	31402170	MGI
involved in vascular wound healing	IDA IDA: Inferred from direct assay	15793281	MGI
involved in wound healing	IDA IDA: Inferred from direct assay	15793281	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	27026367	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17689495	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15793281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heparanase

endo-glucoronidase

endoglycosidase heparanase

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155410	HPSE1-IN-1		/	Unkown
HY-155411	HPSE1-IN-2		/	Unkown
HY-182712	HPSE-IN-2	Inhibitor	/	Unkown
HY-RS06350	HPSE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06351	HPSE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W342853	HPSE-IN-1	Inhibitor	/	Unkown
HY-RS17957	Hpse Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24428	Hpse Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hpse	NCBI	NCBI:10855
Rattus norvegicus	Hpse	NCBI	NCBI:64537

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