Hpse - heparanase Gene

Also Known as Hpa; HSE1; Hpr1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15442

Summary

This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]

Hpse Products (1)

mRNA Protein Name
NM_152803.5 NP_690016.1 heparanase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparanase activity IDA
IDA: Inferred from direct assay
12460766 MGI
Biological Process GO Annotation Evidence References Source
involved in angiogenesis involved in wound healing IDA
IDA: Inferred from direct assay
15793281 MGI
involved in establishment of endothelial barrier IDA
IDA: Inferred from direct assay
27026367 MGI
involved in heparan sulfate proteoglycan catabolic process IDA
IDA: Inferred from direct assay
12460766 MGI
involved in heparin metabolic process IDA
IDA: Inferred from direct assay
27026367 MGI
involved in heparin metabolic process IMP
IMP: Inferred from mutant phenotype
27026367 MGI
involved in positive regulation of hair follicle development IDA
IDA: Inferred from direct assay
15793281 MGI
involved in positive regulation of osteoblast proliferation IDA
IDA: Inferred from direct assay
18589009 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17689495 MGI
involved in protein transmembrane transport IMP
IMP: Inferred from mutant phenotype
27026367 MGI
involved in response to antibiotic IDA
IDA: Inferred from direct assay
31402170 MGI
involved in vascular wound healing IDA
IDA: Inferred from direct assay
15793281 MGI
involved in wound healing IDA
IDA: Inferred from direct assay
15793281 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
27026367 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
17689495 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15793281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heparanase

  • endo-glucoronidase

  • endoglycosidase heparanase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155410 HPSE1-IN-1 / Unkown
HY-155411 HPSE1-IN-2 / Unkown
HY-182712 HPSE-IN-2 Inhibitor / Unkown
HY-RS06350 HPSE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06351 HPSE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W342853 HPSE-IN-1 / Unkown
HY-RS17957 Hpse Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24428 Hpse Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpse NCBI NCBI:10855