Prmt2 - protein arginine N-methyltransferase 2 Gene

Also Known as Hrmt1l1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15468

Summary

Enables beta-catenin binding activity and histone-arginine N-methyltransferase activity. Involved in several processes, including histone methylation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Prmt2 Products (3)

mRNA Protein Name
NM_001077638.2 NP_001071106.1 protein arginine N-methyltransferase 2 isoform 2
NM_001302965.1 NP_001289894.1 protein arginine N-methyltransferase 2 isoform 1
NM_133182.3 NP_573445.2 protein arginine N-methyltransferase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
20708585 MGI
enables histone H3 methyltransferase activity IDA
IDA: Inferred from direct assay
20708585 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16616919 MGI
enables protein-arginine N-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
20798359 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16616919 MGI
Biological Process GO Annotation Evidence References Source
involved in developmental cell growth IMP
IMP: Inferred from mutant phenotype
20798359 MGI
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
16616919 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16616919 MGI
involved in negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16616919 MGI
involved in response to hypoxia IDA
IDA: Inferred from direct assay
16690984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 2

  • heterogeneous nuclear ribonucleoprotein methyltransferase-like 1

  • histone-arginine N-methyltransferase PRMT2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11170 PRMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19732 Prmt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26228 Prmt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt2 NCBI NCBI:3275