Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

Also Known as Htt; Sert; 5-HTT

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15567

About Slc6a4

Chromosome 11: 76,889,429-76,923,166 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 205 orthologues, 20 paralogues and is associated with 59 phenotypes. Broad expression in large intestine adult (RPKM 24.9), small intestine adult (RPKM 15.4) and 16 other tissues.

Summary

Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a4 Products (1)

mRNA	Protein	Name
NM_010484.2	NP_034614.2	sodium-dependent serotonin transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	17452640	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17452640	MGI
enables serotonin:sodium:chloride symporter activity	IDA IDA: Inferred from direct assay	9037532	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain morphogenesis	IMP IMP: Inferred from mutant phenotype	19208814	MGI
involved in enteric nervous system development	IMP IMP: Inferred from mutant phenotype	27111230	MGI
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	19208814	MGI
involved in neurotransmitter reuptake	IDA IDA: Inferred from direct assay	9037532	MGI
involved in neurotransmitter reuptake	IMP IMP: Inferred from mutant phenotype	9037532	MGI
involved in neurotransmitter transport	IMP IMP: Inferred from mutant phenotype	20858707	MGI
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	18317590	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19308295	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19308295	MGI
involved in serotonin transport	IMP IMP: Inferred from mutant phenotype	19308295	MGI
involved in serotonin uptake	IDA IDA: Inferred from direct assay	17452640	MGI
involved in serotonin uptake	IMP IMP: Inferred from mutant phenotype	9547354	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	29038237	MGI
located in synapse	IDA IDA: Inferred from direct assay	29038237	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a4 Protein Structure

5HT_transport_N

SLC6sbd_SERT

0
100
200
300
400
500
600
630 a.a.

Protein Preferred Names	Protein Names
sodium-dependent serotonin transporter	5-hydroxytryptamine (serotonin) transporter 5HT transporter 5HTT Sodium-dependent serotonin transporter (5HT transporter) (5HTT) solute carrier family 6 member 4

Slc6a4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Slc6a4	Q60857	Nos1	Mus musculus	Q9Z0J4	Pull Down	17452640
Intra	Slc6a4	Q60857	Nos1	Mus musculus	Q9Z0J4	Anti Tag CoIP	17452640

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110023R	Zimelidine dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-RS13311	SLC6A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13312	Slc6a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13313	Slc6a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a4	NCBI	NCBI:6532