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PRUNE2 - prune homolog 2 with BCH domain Gene

Also Known as BMCC1; BNIPXL; C9orf65; KIAA0367

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 158471

About PRUNE2

Cytogenetic location: 9q21.2 Genomic coordinates (GRCh38): 9:76,611,376-76,906,114 (from NCBI)

This gene has 14 transcripts (splice variants), 288 orthologues and 3 paralogues. Broad expression in prostate (RPKM 10.8), brain (RPKM 9.0) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate Cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate Cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate Cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes Adenosine Deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

PRUNE2 Products (7)

mRNA	Protein	Name
NM_001308047.2	NP_001294976.1	protein prune homolog 2 isoform 2
NM_001308048.2	NP_001294977.1	protein prune homolog 2 isoform 3
NM_001308049.2	NP_001294978.1	protein prune homolog 2 isoform 4
NM_001308050.2	NP_001294979.1	protein prune homolog 2 isoform 5
NM_001308051.2	NP_001294980.1	protein prune homolog 2 isoform 6
NM_001330680.2	NP_001317609.1	protein prune homolog 2 isoform 7
NM_015225.3	NP_056040.2	protein prune homolog 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRUNE2 Protein Structure

DHHA2

BNIP2

CRAL_TRIO_2

0
500
1000
1500
2000
2500
3088 a.a.

Protein Preferred Names	Protein Names
protein prune homolog 2	BCH motif-containing molecule at the carboxyl terminal region 1

PRUNE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRUNE2	Q8WUY3	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	HSP90AA1	Homo sapiens	P07900	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	HSP90AA1	Homo sapiens	P07900	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	HSP90AA1	Homo sapiens	P07900	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	AKT1	Homo sapiens	P31749	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	AKT1	Homo sapiens	P31749	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	AKT1	Homo sapiens	P31749	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	HSPD1	Homo sapiens	P10809	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	HSPD1	Homo sapiens	P10809	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	HSPD1	Homo sapiens	P10809	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	GAPDH	Homo sapiens	P04406	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	GAPDH	Homo sapiens	P04406	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	GAPDH	Homo sapiens	P04406	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PRUNE2	Q8WUY3	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	CRYAB	Homo sapiens	P02511	Y2H Array	32814053
Intra	PRUNE2	Q8WUY3	CRYAB	Homo sapiens	P02511	Validated Y2H	32814053
Intra	PRUNE2	Q8WUY3	CRYAB	Homo sapiens	P02511	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Water-Clear Cell Adenoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Prostate Sarcoma	Sarcoma Of The Prostate
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11264	PRUNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRUNE2	VGNC	VGNC:82382
Bos taurus	PRUNE2	VGNC	VGNC:33429
Macaca mulatta	PRUNE2	VGNC	VGNC:76314
Rattus norvegicus	PRUNE2	RGD	RGD:1311350
Mus musculus	PRUNE2	MGD	MGI:1925004
Canis familiaris	PRUNE2	VGNC	VGNC:45078
Others	PRUNE2	NCBI