Id3 - inhibitor of DNA binding 3 Gene

Also Known as Idb3; Hlh462; bHLHb25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15903

Summary

Enables leptomycin B binding activity; protein domain specific binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of myoblast differentiation; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including animal organ development; cellular response to leptomycin B; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id3 Products (1)

mRNA Protein Name
NM_008321.2 NP_032347.1 DNA-binding protein inhibitor ID-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
8759016 MGI
enables leptomycin B binding IDA
IDA: Inferred from direct assay
23523789 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8759016 MGI
enables protein domain specific binding IDA
IDA: Inferred from direct assay
2000388 MGI
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
17681138 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leptomycin B IDA
IDA: Inferred from direct assay
23523789 MGI
involved in central nervous system development IEP
IEP: Inferred from expression pattern
7655079 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19217292 MGI
acts upstream of or within epithelial cell differentiation IDA
IDA: Inferred from direct assay
16407553 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15472070 MGI
involved in metanephros development IEP
IEP: Inferred from expression pattern
7655079 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19217292 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
23523789 MGI
involved in negative regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
23824195 MGI
acts upstream of or within negative regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15161906 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
2000388 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19217292 MGI
involved in notochord development IEP
IEP: Inferred from expression pattern
7655079 MGI
involved in odontogenesis IEP
IEP: Inferred from expression pattern
7655079 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
17681138 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
17681138 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8083744 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
23523789 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein inhibitor ID-3

  • ID-like protein inhibitor HLH 462

  • inhibitor of differentiation 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-110245 DMH2 Inducer 99.84% Unkown
HY-155705 BMP agonist 1 / Unkown
HY-RS06524 ID3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143623S Neo Spiramycin I-d3 / Unkown
HY-181116 Anticancer agent 298 / Unkown
HY-RS17523 Id3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23980 Id3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Id3 NCBI NCBI:3399