Irf9 - interferon regulatory factor 9 Gene

Also Known as p48; Irf-9; Isgf3g

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16391

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 65. Orthologous to human IRF9 (interferon regulatory factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Irf9 Products (3)

mRNA Protein Name
NM_001159417.1 NP_001152889.1 interferon regulatory factor 9 isoform 1
NM_001159418.1 NP_001152890.1 interferon regulatory factor 9 isoform 2
NM_008394.3 NP_032420.1 interferon regulatory factor 9 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within type I interferon production IMP
IMP: Inferred from mutant phenotype
15800576 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 9

  • IFN-alpha-responsive transcription factor subunit

  • ISGF-3 gamma

  • ISGF3 p48 subunit

  • interferon dependent positive acting transcription factor 3 gamma

  • interferon-stimulated gene factor 3 gamma

  • transcriptional regulator ISGF3 subunit gamma

Irf9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Irf9 Q61179 Stat2 Mus musculus Q9QXJ2
Y2H
15102471
Intra
Irf9 Q61179 Stat2 Mus musculus Q9QXJ2
Y2H Array
20211142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06913 IRF9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17690 Irf9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24152 Irf9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99666 Interferon alfa-2b Agonist ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf9 NCBI NCBI:10379