Itgb2 - integrin beta 2 Gene

Also Known as 2E6; LAD; Cd18; Lfa1; MF17; LCAMB

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16414

Summary

Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of Integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (Integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Itgb2 Products (1)

mRNA	Protein	Name
NM_008404.5	NP_032430.2	integrin beta-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IMP IMP: Inferred from mutant phenotype	18981818	MGI
contributes to cargo receptor activity	IMP IMP: Inferred from mutant phenotype	20199584	MGI
enables complement component C3b binding	IGI IGI: Inferred from genetic interaction	20199584	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19234461	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	15210787	MGI
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	20199584	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	19342649	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	10528208	MGI
acts upstream of or within cell-cell adhesion	IGI IGI: Inferred from genetic interaction	16093349	MGI
involved in cell-cell adhesion	IGI IGI: Inferred from genetic interaction	12652296	MGI
acts upstream of or within cellular extravasation	IMP IMP: Inferred from mutant phenotype	10528208	MGI
involved in cellular response to low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	15249579	MGI
acts upstream of or within neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	10528208	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	20199584	MGI
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	24458438	MGI
involved in receptor internalization	IDA IDA: Inferred from direct assay	23395392	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	20199584	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17023661	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19299737	MGI
part of integrin alphaM-beta2 complex	IMP IMP: Inferred from mutant phenotype	20199584	MGI
located in membrane	IDA IDA: Inferred from direct assay	10601245	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	10601245	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
integrin beta-2	Mac-1 beta cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta complement receptor C3 subunit beta lymphocyte function associated antigen 1 macrophage antigen-1 beta

Itgb2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810219	Integrin β2/ITGB2/CD18 Antibody (YA9563)	WB, IP	mouse

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99946	Erlizumab	Inhibitor	98.49%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06965	ITGB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16847	Itgb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23288	Itgb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgb2	NCBI	NCBI:3689