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Ldb1 - LIM domain binding 1 Gene

Also Known as NLI; CLIM2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16825

Summary

Enables several functions, including LIM domain binding activity; protein homodimerization activity; and protein self-association. Contributes to DNA binding activity. Involved in several processes, including histone H3-K4 acetylation; negative regulation of erythrocyte differentiation; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; epithelial structure maintenance; and hair follicle development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; eye; and genitourinary system. Used to study nail-patella syndrome. Orthologous to human LDB1 (LIM domain binding 1). [provided by Alliance of Genome Resources, Apr 2022]

Ldb1 Products (5)

mRNA	Protein	Name
NM_001113408.3	NP_001106879.1	LIM domain-binding protein 1 isoform 1
NM_001360336.2	NP_001347265.1	LIM domain-binding protein 1 isoform 2
NM_001410966.1	NP_001397895.1	LIM domain-binding protein 1 isoform 2
NM_001410967.1	NP_001397896.1	LIM domain-binding protein 1 isoform 3
NM_010697.3	NP_034827.1	LIM domain-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	9391090	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18539116	MGI
enables LIM domain binding	IDA IDA: Inferred from direct assay	8876198	MGI
enables LIM domain binding	IPI IPI: Inferred from physical interaction	9192866	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18550854	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	11882901	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19323994	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8918878	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9315627	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	18539116	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12490556	MGI
acts upstream of or within anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	12490556	MGI
acts upstream of cell adhesion	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within cellular component assembly	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	17664423	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	17664423	MGI
acts upstream of or within epithelial structure maintenance	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	12490556	MGI
acts upstream of or within hair follicle development	IGI IGI: Inferred from genetic interaction	17991461	MGI
involved in head development	IGI IGI: Inferred from genetic interaction	15857913	MGI
involved in negative regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9391090	MGI
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	8876198	MGI
acts upstream of or within positive regulation of cell adhesion	IGI IGI: Inferred from genetic interaction	17991461	MGI
involved in positive regulation of hemoglobin biosynthetic process	IMP IMP: Inferred from mutant phenotype	20570862	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9192866	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9192866	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18539116	MGI
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20570862	MGI
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	19675209	MGI
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	19675209	MGI
involved in regulation of kinase activity	IDA IDA: Inferred from direct assay	19675209	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	17991461	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15857913	MGI
involved in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP IMP: Inferred from mutant phenotype	20570862	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	9860983	MGI
located in cell leading edge	IDA IDA: Inferred from direct assay	19675209	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8876198	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	15857913	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	9391090	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19323994	MGI
part of transcription regulator complex	IMP IMP: Inferred from mutant phenotype	18539116	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
LIM domain-binding protein 1	LIM domain-binding factor CLIM2 carboxyl-terminal LIM domain-binding protein 2 nuclear LIM interactor

Ldb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ldb1	P70662	Tcf4	Mus musculus	Q60722	Anti Bait CoIP	16407974
Intra	Ldb1	P70662	Isl1	Mus musculus	P61372	Y2H	18583962
Intra	Ldb1	P70662	Lhx3	Mus musculus	P50481	Y2H	18583962
Intra	Ldb1	P70662	Tal1	Mus musculus	P22091	Anti Bait CoIP	16407974

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07568	LDB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07569	LDB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19348	Ldb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25839	Ldb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldb1	NCBI	NCBI:8861