Limk2 - LIM motif-containing protein kinase 2 Gene

Also Known as whe; Limk-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16886

About Limk2

Chromosome 11: 3,294,256-3,359,189 reverse strand.GRCm39:CM001004.3

This gene has 13 transcripts (splice variants), 205 orthologues, 23 paralogues and is associated with 31 phenotypes. Ubiquitous expression in placenta adult (RPKM 23.2), colon adult (RPKM 19.9) and 27 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Limk2 Products (9)

mRNA Protein Name
NM_001402862.1 NP_001389791.1 LIM domain kinase 2 isoform g
NM_001402860.1 NP_001389789.1 LIM domain kinase 2 isoform 3
NM_001402861.1 NP_001389790.1 LIM domain kinase 2 isoform f
NM_010718.4 NP_034848.1 LIM domain kinase 2 isoform a
NM_173053.2 NP_774958.1 LIM domain kinase 2 isoform b
NM_001034030.2 NP_001029202.1 LIM domain kinase 2 isoform c
NM_001402864.1 NP_001389793.1 LIM domain kinase 2 isoform c
NM_001402863.1 NP_001389792.1 LIM domain kinase 2 isoform h
NM_001361623.1 NP_001348552.1 LIM domain kinase 2 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16399995 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
11784110 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cornea development in camera-type eye IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
11784110 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11784110 MGI
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network IDA
IDA: Inferred from direct assay
16399995 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16399995 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16399995 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Limk2 Protein Structure

LIM

LIM: cl02475 (11 - 64)

LIM2_LIMK2

LIM2_LIMK2: cd09465 (66 - 124)

PDZ

PDZ: pfam00595 (151 - 235)

STKc_LIMK2

STKc_LIMK2: cd14222 (336 - 607)

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  • 638 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 2

  • LIM kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18305 BMS-5 Inhibitor 99.84% Unkown
HY-18304 BMS-3 Inhibitor 99.89% Unkown
HY-122630 TH-257 Inhibitor 98.36% Unkown
HY-19352 T56-LIMKi Inhibitor 98.67% Unkown
HY-137346 DD-03-156 Degrader 99.90% Unkown
HY-120025 CRT0105950 Inhibitor 99.76% Unkown
HY-151539 TH470 Inhibitor 99.62% Unkown
HY-148063 DB0614 96.07% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor 99.1% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-174229 SM311 Inhibitor / Unkown
HY-175656 MDI-117740 Inhibitor / Unkown
HY-125444 TH251 Inhibitor / Unkown
HY-14226 LIMK-IN-3 Inhibitor / Unkown
HY-178122 THNAN69 Degrader / Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Limk2 NCBI NCBI:3985