Zbtb7a - zinc finger and BTB domain containing 7a Gene

Also Known as Lrf; FBI-1; Zbtb7; Pokemon; 9030619K07Rik; 9130006G12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16969

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Histone Acetyltransferase binding activity. Involved in several processes, including hemopoiesis; nucleic acid metabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of DNA-dependent protein kinase complex. Colocalizes with site of double-strand break. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb7a Products (8)

mRNA	Protein	Name
NM_001404861.1	NP_001391790.1	zinc finger and BTB domain-containing protein 7A
NM_001404862.1	NP_001391791.1	zinc finger and BTB domain-containing protein 7A
NM_001404863.1	NP_001391792.1	zinc finger and BTB domain-containing protein 7A
NM_001404864.1	NP_001391793.1	zinc finger and BTB domain-containing protein 7A
NM_001404865.1	NP_001391794.1	zinc finger and BTB domain-containing protein 7A
NM_001404866.1	NP_001391795.1	zinc finger and BTB domain-containing protein 7A
NM_001404867.1	NP_001391796.1	zinc finger and BTB domain-containing protein 7A
NM_010731.4	NP_034861.3	zinc finger and BTB domain-containing protein 7A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15337766	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15662416	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	29813070	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15337766	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15337766	MGI
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	15337766	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15337766	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15662416	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	17495164	MGI
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29813070	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	29813070	MGI
involved in double-strand break repair via classical nonhomologous end joining	IDA IDA: Inferred from direct assay	26446488	MGI
involved in erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	26816381	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15337766	MGI
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	17495164	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15662416	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15337766	MGI
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	29813070	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of DNA-dependent protein kinase complex	IMP IMP: Inferred from mutant phenotype	26446488	MGI
colocalizes with site of double-strand break	IDA IDA: Inferred from direct assay	26446488	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger and BTB domain-containing protein 7A	POK erythroid myeloid ontogenic factor POZ and Krueppel erythroid myeloid ontogenic factor leukemia/lymphoma related factor

Zbtb7a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Zbtb7a	O88939	Hdac1	Mus musculus	O09106	Anti Tag CoIP	26816381
Intra	Zbtb7a	O88939	Hdac1	Mus musculus	O09106	Anti Bait CoIP	15337766

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-175742	BMS-986470	Degrader	99.78%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152775	RK-701	Inhibitor	98.01%	Unkown
HY-178486	SH6		99.43%	Unkown
HY-175742A	(R)-BMS-986470		99.93%	Unkown
HY-RS15979	ZBTB7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19274	Zbtb7a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25763	Zbtb7a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zbtb7a	NCBI	NCBI:51341