ZBTB7A - zinc finger and BTB domain containing 7A Gene

Homo sapiens

Also known as LRF; FBI1; FBI-1; TIP21; ZBTB7; MNDLFH; ZNF857A; pokemon

Gene ID: 51341 | Gene type: protein coding

About ZBTB7A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,043,303-4,066,899 (from NCBI)

This gene has 2 transcripts (splice variants), 114 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues.

Summary

Enables several functions, including SMAD binding activity; Androgen Receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB7A Products(2)

mRNA	Protein	Name
NM_001317990.2	NP_001304919.1	zinc finger and BTB domain-containing protein 7A
NM_015898.4	NP_056982.1	zinc finger and BTB domain-containing protein 7A

ZBTB7A Protein Structure

BTB

zf-H2C2_2

0
100
200
300
400
500
584 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 7A

HIV-1 1st-binding protein 1

Related Diseases

Diseases

Alias

Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin

MNDLFH

Photosensitive Epilepsy

Pse	Photogenic Epilepsy
Photoparoxysmal Response	Reflex Epilepsy, Photosensitive
Photoparoxysmal Response 1

Endometrial Mixed Adenocarcinoma

Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin	Delta-Beta-Thalassemia
Delta-Beta Thalassemia	Delta Beta-Thalassemia
HBFQTL1	Hemoglobin F, Hereditary Persistence Of
Hpfh	Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related
Hemoglobin, Fetal, Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Thalassemia
Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]	Fetal Haemoglobin
Persistence Of Fetal Haemoglobin	Persistent Haemoglobin F

Hemoglobinopathy

Hemoglobinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152775	RK-701	Inhibitor	98.04%	Unkown
HY-RS15979	ZBTB7A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZBTB7A	MGD	MGI:1335091
Rattus norvegicus	ZBTB7A	RGD	RGD:620946
Canis familiaris	ZBTB7A	VGNC	VGNC:48544
Bos taurus	ZBTB7A	VGNC	VGNC:37089

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