COMMD6 - COMM domain containing 6 Gene

Also Known as Acrg

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 170622

About COMMD6

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,525,214-75,549,439 (from NCBI)

This gene has 13 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 31.5), adrenal (RPKM 27.0) and 25 other tissues.

Summary

COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

COMMD6 Products (5)

mRNA Protein Name
NM_001287392.2 NP_001274321.1 COMM domain-containing protein 6 isoform c
NM_001287393.2 NP_001274322.1 COMM domain-containing protein 6 isoform c
NM_001287394.2 NP_001274323.1 COMM domain-containing protein 6 isoform c
NM_203495.4 NP_987091.1 COMM domain-containing protein 6 isoform b
NM_203497.4 NP_987093.1 COMM domain-containing protein 6 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
16573520 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16573520 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD6 Protein Structure

COMM_domain

COMM_domain: COMM domain (13 - 84)

  • 0
  • 85 a.a.
Protein Preferred Names Protein Names

COMM domain-containing protein 6

  • Acrg embryonic lethality minimal region ortholog

COMMD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COMMD6 Q7Z4G1 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
35271311
Intra
COMMD6 Q7Z4G1 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
37172566
Intra
COMMD6 Q7Z4G1 CCDC93 Homo sapiens Q567U6
Pull Down
25355947
Intra
COMMD6 Q7Z4G1 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
33961781
Intra
COMMD6 Q7Z4G1 COMMD1 Homo sapiens Q8N668
Validated Y2H
32296183
Intra
COMMD6 Q7Z4G1 COMMD1 Homo sapiens Q8N668
Y2H Array
32296183
Intra
COMMD6 Q7Z4G1 COMMD1 Homo sapiens Q8N668
Y2H Prey Pooling
25416956
Intra
COMMD6 Q7Z4G1 COMMD1 Homo sapiens Q8N668
Y2H Prey Pooling
32296183
Intra
COMMD6 Q7Z4G1 COMMD1 Homo sapiens Q8N668
Anti Bait CoIP
23563313
Intra
COMMD6 Q7Z4G1 COMMD9 Homo sapiens Q9P000
Anti Tag CoIP
35271311
Intra
COMMD6 Q7Z4G1 COMMD9 Homo sapiens Q9P000
Anti Tag CoIP
37172566
Intra
COMMD6 Q7Z4G1 COMMD9 Homo sapiens Q9P000
Validated Y2H
32296183
Intra
COMMD6 Q7Z4G1 COMMD9 Homo sapiens Q9P000
Anti Tag CoIP
33961781
Intra
COMMD6 Q7Z4G1 HSPA6 Homo sapiens P17066
Y2H Array
32296183
Intra
COMMD6 Q7Z4G1 HSPA6 Homo sapiens P17066
Y2H Prey Pooling
32296183
Intra
COMMD6 Q7Z4G1 CCDC22 Homo sapiens O60826
Anti Tag CoIP
37172566
Intra
COMMD6 Q7Z4G1 CCDC22 Homo sapiens O60826
Anti Tag CoIP
33961781
Intra
COMMD6 Q7Z4G1 CCDC22 Homo sapiens O60826
Anti Bait CoIP
23563313
Intra
COMMD6 Q7Z4G1 CCDC22 Homo sapiens O60826
Pull Down
23563313
Intra
COMMD6 Q7Z4G1 CCDC22 Homo sapiens O60826
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03013 COMMD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus COMMD6 VGNC VGNC:61076
Mus musculus COMMD6 MGD MGI:1913450
Canis familiaris COMMD6 VGNC VGNC:54288
Rattus norvegicus COMMD6 RGD RGD:1560745
Macaca mulatta COMMD6 VGNC VGNC:103800
Others COMMD6 NCBI