Asic3 - acid-sensing (proton-gated) ion channel 3 Gene

Also Known as Accn3; TNAC1; DRASIC; SLNAC1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171209

Summary

Enables cation channel activity and enterobactin transmembrane transporter activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Is integral component of plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Asic3 Products (2)

mRNA Protein Name
NM_001310474.1 NP_001297403.1 acid-sensing ion channel 3 isoform 2
NM_183000.2 NP_892045.2 acid-sensing ion channel 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enterobactin transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
19590043 MGI
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
11854527 MGI
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
11854527 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of chemical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12060708 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
19590043 MGI
acts upstream of or within monoatomic cation transport IDA
IDA: Inferred from direct assay
11854527 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
11854527 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
19590043 MGI
acts upstream of or within response to acidic pH IDA
IDA: Inferred from direct assay
11854527 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
11754838 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
11754838 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11854527 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid-sensing ion channel 3

  • amiloride-sensitive cation channel 3

  • dorsal root ASIC

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0814 DAPI dihydrochloride Inhibitor 99.90% Unkown
HY-D1738 DAPI dilactate 99.0% Unkown
HY-D2868 DAPI Inhibitor 98.01% Unkown
HY-107757 GMQ hydrochloride Activator 99.86% Unkown
HY-122135 A-317567 Inhibitor 99.34% Unkown
HY-131879 NS383 99.83% Unkown
HY-DY1081 DAPI dihydrochloride (solution) Inhibitor / Unkown
HY-P1346A APETx2 TFA Inhibitor 99.57% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-100939 4-Chlorophenylguanidine hydrochloride Agonist 99.07% Unkown
HY-P1346 APETx2 Inhibitor / Unkown
HY-155017 6-Iodoamiloride Inhibitor / Unkown
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / Unkown
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / Unkown
HY-RS01091 ASIC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17225 Asic3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23678 Asic3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asic3 NCBI NCBI:9311