Mbd2 - methyl-CpG binding domain protein 2 Gene

Also Known as MBD2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17191

Summary

Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including maternal behavior; negative regulation of transcription by RNA polymerase II; and positive regulation of Wnt signaling pathway. Located in cytoplasm; heterochromatin; and nucleus. Part of histone deacetylase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb ectoderm; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mbd2 Products (2)

mRNA Protein Name
NM_001311071.1 NP_001298000.1 methyl-CpG-binding domain protein 2 isoform 2
NM_010773.2 NP_034903.2 methyl-CpG-binding domain protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9774669 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16608912 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
23335972 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
15342650 MGI
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
15342650 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23335972 MGI
enables siRNA binding IDA
IDA: Inferred from direct assay
15342650 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18644872 MGI
acts upstream of or within maternal behavior IMP
IMP: Inferred from mutant phenotype
11274056 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11242117 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18644872 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
11274056 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18644872 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
9774669 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17546630 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
14519686 MGI
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
11274056 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
17546630 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9774669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methyl-CpG-binding domain protein 2

  • methyl-CpG-binding protein MBD2

  • testis-specific methyl-CpG binding protein 2

Mbd2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mbd2 Q9Z2E1 Mbd2 Mus musculus Q9Z2E1
Anti Tag CoIP
23335972
Intra
Mbd2 Q9Z2E1 CHD4 Homo sapiens F5GWX5
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 GATAD2B Homo sapiens Q8WXI9
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 GATAD2A Homo sapiens Q86YP4
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 DHX30 Homo sapiens Q7L2E3-2
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 DHX36 Homo sapiens Q9H2U1
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 Mbd2 Mus musculus Q9Z2E1
Pull Down
23335972
Intra
Mbd2 Q9Z2E1 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
26496610
Intra
Mbd2 Q9Z2E1 CDK2AP1 Homo sapiens F5GZF0
Anti Tag CoIP
26496610
Cross
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
Anti Tag CoIP
23335972
Cross
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
IF
23335972
Cross
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
Pull Down
23335972
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131031 KCC-07 99.97% Unkown
HY-RS08182 MBD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128562 CS-1-69 / Unkown
HY-179238 CS-1-103 Inhibitor / Unkown
HY-186232 CS-1-102 / Unkown
HY-186233 CS-1-174 Inhibitor / Unkown
HY-RS03948 DPEP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17814 Mbd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18658 Dpep2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24283 Mbd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mbd2 NCBI NCBI:8932