Mbd3 - methyl-CpG binding domain protein 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17192

Summary

This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of Leukemia Inhibitory Factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Mbd3 Products (2)

mRNA Protein Name
NM_001306143.1 NP_001293072.1 methyl-CpG-binding domain protein 3 isoform 2
NM_013595.3 NP_038623.1 methyl-CpG-binding domain protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9774669 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16462733 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17287250 MGI
acts upstream of or within tissue development IMP
IMP: Inferred from mutant phenotype
17287250 MGI
Cellular Component GO Annotation Evidence References Source
part of NuRD complex IPI
IPI: Inferred from physical interaction
16462733 MGI
located in chromatin IDA
IDA: Inferred from direct assay
9774669 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17546630 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
14643676 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
17546630 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9774669 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methyl-CpG-binding domain protein 3

  • methyl-CpG-binding protein MBD3

Mbd3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mbd3 Q9Z2D8 Mecom Mus musculus P14404
TAP
18500823
Intra
Mbd3 Q9Z2D8 Mecom Mus musculus P14404
Anti Bait CoIP
18500823
Intra
Mbd3 Q9Z2D8 Mecom Mus musculus P14404
GMS
18500823
Intra
Mbd3 Q9Z2D8 Mecom Mus musculus P14404
Confocal
18500823
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08183 MBD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19351 Mbd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25842 Mbd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99506 Tamrintamab 98.51% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mbd3 NCBI NCBI:53615