Mcm2 - minichromosome maintenance complex component 2 Gene

Also Known as BM28; CDCL1; Mcmd2; mKIAA0030

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17216

Summary

Enables DNA replication origin binding activity; enzyme binding activity; and histone binding activity. Acts upstream of or within DNA unwinding involved in DNA replication; cellular response to interleukin-4; and nucleosome assembly. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including central nervous system; future brain; inner cell mass; limb; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]

Mcm2 Products (1)

mRNA Protein Name
NM_008564.2 NP_032590.2 DNA replication licensing factor MCM2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA replication origin binding IDA
IDA: Inferred from direct assay
12941272 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
24115439 MGI
enables histone binding IDA
IDA: Inferred from direct assay
10531422 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
10531422 MGI
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
acts upstream of or within nucleosome assembly IDA
IDA: Inferred from direct assay
10531422 MGI
Cellular Component GO Annotation Evidence References Source
part of MCM complex IDA
IDA: Inferred from direct assay
10567526 MGI
part of nuclear origin of replication recognition complex IDA
IDA: Inferred from direct assay
12941272 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10531422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA replication licensing factor MCM2

  • mini chromosome maintenance deficient 2

  • minichromosome maintenance deficient 2 mitotin

  • minichromosome maintenance protein 2 homolog

  • nuclear protein BM28

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143432A (S)-Cdc7-IN-18 Inhibitor / Unkown
HY-RS08234 MCM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08240 MCM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17409 Mcm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23863 Mcm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcm2 NCBI NCBI:4171