Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Also Known as AGT; Agat

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17314

About Mgmt

Chromosome 7: 136,496,343-136,731,995 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 189 orthologues and is associated with 9 phenotypes. Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.) and 24 other tissues.

Summary

Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products (10)

mRNA Protein Name
NM_001412701.1 NP_001399630.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001412704.1 NP_001399633.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412703.1 NP_001399632.1 methylated-DNA--protein-cysteine methyltransferase isoform 5
NM_001412698.1 NP_001399627.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412702.1 NP_001399631.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001377037.2 NP_001363966.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412697.1 NP_001399626.1 methylated-DNA--protein-cysteine methyltransferase isoform 2
NM_008598.4 NP_032624.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412699.1 NP_001399628.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412700.1 NP_001399629.1 methylated-DNA--protein-cysteine methyltransferase isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables methyltransferase activity IDA
IDA: Inferred from direct assay
1554415 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA alkylation repair IDA
IDA: Inferred from direct assay
1554415 MGI
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
9560238 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
13679151 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
13679151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgmt Protein Structure

AdaB

AdaB: COG0350 (5 - 177)

  • 0
  • 100
  • 200
  • 211 a.a.
Protein Preferred Names Protein Names

methylated-DNA--protein-cysteine methyltransferase

  • 6-O-methylguanine-DNA methyltransferase

  • O-6-alkylguanine-DNA alkyltransferase

  • O-6-methylguanine-DNA-alkyltransferase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13668 Lomeguatrib Inhibitor 99.77% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13057 O6BTG-octylglucoside Inhibitor 95.0% Unkown
HY-175299 Hedgehog IN-11 Inhibitor / Unkown
HY-186228 Anticancer agent 333 / Unkown
HY-180540 MGMT-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgmt NCBI NCBI:4255