2. Gene
  3. Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Mgmt - O-6-methylguanine-DNA methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AGT; Agat

Gene ID: 17314 | Gene type: protein coding

About Mgmt

Chromosome 7: 136,496,343-136,731,995 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 189 orthologues and is associated with 9 phenotypes. Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.) and 24 other tissues.

Summary

Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products(10)

mRNA Protein Name
NM_001412701.1 NP_001399630.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001412704.1 NP_001399633.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412703.1 NP_001399632.1 methylated-DNA--protein-cysteine methyltransferase isoform 5
NM_001412698.1 NP_001399627.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412702.1 NP_001399631.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001377037.2 NP_001363966.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412697.1 NP_001399626.1 methylated-DNA--protein-cysteine methyltransferase isoform 2
NM_008598.4 NP_032624.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412699.1 NP_001399628.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412700.1 NP_001399629.1 methylated-DNA--protein-cysteine methyltransferase isoform 3

Mgmt Protein Structure

AdaB

AdaB: COG0350 (5 - 177)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

methylated-DNA--protein-cysteine methyltransferase

6-O-methylguanine-DNA methyltransferase

O-6-alkylguanine-DNA alkyltransferase

O-6-methylguanine-DNA-alkyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13668 Lomeguatrib Inhibitor 99.70% Unkown
HY-13057 O6BTG-octylglucoside Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgmt NCBI NCBI:4255