Prdx1 - peroxiredoxin 1 Gene

Also Known as PAG; OSF3; Paga; PrxI; TDX2; TPxA; prx1; MSP23; NkefA; OSF-3; PrdxI; Tdpx2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18477

Summary

Enables identical protein binding activity. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; regulation of intracellular signal transduction; and removal of superoxide radicals. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Prdx1 Products (1)

mRNA	Protein	Name
NM_011034.5	NP_035164.1	peroxiredoxin-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21516123	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21516123	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of negative effect canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15858817	MGI
acts upstream of or within erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	12891360	MGI
acts upstream of or within fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12891360	MGI
acts upstream of or within natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	12891360	MGI
acts upstream of negative effect regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15858817	MGI
acts upstream of or within regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	16880205	MGI
acts upstream of or within removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	16170382	MGI
acts upstream of or within response to oxidative stress	IDA IDA: Inferred from direct assay	8360158	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15858817	MGI
acts upstream of or within response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	12891360	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
peroxiredoxin-1	Trx dependent peroxide reductase 2 macrophage 23 Kd stress protein macrophage 23 kDa stress protein macrophage 23kDa stress protein macrophase stress protein 22kDa macrophase stress protein 23 kd osteoblast-specific factor 3 proliferation-associate

Recombinant Prdx1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73713	PRDX1 Protein, Mouse (His)	P35700 (M1-K199)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149394	PRDX1-IN-1		98.04%	Unkown
HY-122936	Tanshindiol C		98.47%	Unkown
HY-171272	PRDX1-IN-3		99.52%	Unkown
HY-RS11074	PRDX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158368	PRDX1-IN-2		/	Unkown
HY-174412	LC-PDin06	Inhibitor	/	Unkown
HY-182287	PRDX1-IN-4		/	Unkown
HY-182308	LC-PDA-01	Inhibitor	/	Unkown
HY-N14780	Pochonin D		/	Unkown
HY-RS16694	Prdx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23129	Prdx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prdx1	NCBI	NCBI:5052