2. Immunology/Inflammation Apoptosis NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) MDM-2/p53
  4. PRDX1-IN-3

PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect.

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PRDX1-IN-3

PRDX1-IN-3 Chemical Structure

CAS No. : 2566976-46-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

PRDX1-IN-3 Related Antibodies

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Description

PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect[1].

IC50 & Target

PRDX1[1]
Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.28 μM
Compound: 24; 19-048
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
[PMID: 38142509]
HCT-116 IC50
0.8 μM
Compound: 3; 19-048
Inhibition of cell viability in human HCT-116 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human HCT-116 cells incubated for 72 hrs by Cell Titer Glo assay
[PMID: 38679872]
SW-620 IC50
0.28 μM
Compound: 24; 19-048
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth
[PMID: 38142509]
SW-620 IC50
0.33 μM
Compound: 3; 19-048
Inhibition of cell viability in human SW620 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human SW620 cells incubated for 72 hrs by Cell Titer Glo assay
[PMID: 38679872]
Molecular Weight

550.73

Formula

C33H46N2O5
CAS No.
Appearance

Solid

Color

orange

SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)NC(N[C@@H](C)C(OC)=O)=O)C)(CC[C@@]4(C2=CC=C5C4=CC(C(O)=C5C)=O)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (22.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8158 mL 9.0789 mL 18.1577 mL
5 mM 0.3632 mL 1.8158 mL 3.6315 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8158 mL 9.0789 mL 18.1577 mL 45.3943 mL
5 mM 0.3632 mL 1.8158 mL 3.6315 mL 9.0789 mL
10 mM 0.1816 mL 0.9079 mL 1.8158 mL 4.5394 mL
15 mM 0.1211 mL 0.6053 mL 1.2105 mL 3.0263 mL
20 mM 0.0908 mL 0.4539 mL 0.9079 mL 2.2697 mL
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PRDX1-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRDX1-IN-32566976-46-1 Reactive Oxygen Species (ROS)MDM-2/p53Inhibitorinhibitorinhibit

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