LC-PDin06
LC-PDin06 is a selective PRDX1 inhibitor with an IC50 of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels.
For research use only. We do not sell to patients.
- CAS No.: 2027514-32-3
- Formula: C35H47N3O3
- Molecular Weight:557.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
0.042 μM
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.37 μM
Compound: CEL21
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27647369] |
| MCF7 | IC50 |
1.84 μM
Compound: CEL21
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27647369] |
| PANC-1 | IC50 |
1.53 μM
Compound: CEL21
|
Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 27647369] |
Chemical Information
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CAS No. 2027514-32-3
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Molecular Weight 557.77
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Formula C35H47N3O3
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SMILES
OC1=C(C)C2=CC=C3[C@@]4(C)CC[C@@]5(C)CC[C@@](C)(C(NCCCN6C=CN=C6)=O)C[C@]([H])5[C@@](C)4CC[C@](C)3C2=CC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)