2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. LC-PDin06

LC-PDin06 is a selective PRDX1 inhibitor with an IC50 of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels.

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LC-PDin06

LC-PDin06 Chemical Structure

CAS No. : 2027514-32-3

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LC-PDin06 Related Antibodies

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Description

LC-PDin06 is a selective PRDX1 inhibitor with an IC50 of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels[1].

IC50 & Target

0.042 μM
Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.37 μM
Compound: CEL21
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27647369]
MCF7 IC50
1.84 μM
Compound: CEL21
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27647369]
PANC-1 IC50
1.53 μM
Compound: CEL21
Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27647369]
Molecular Weight

557.77

Formula

C35H47N3O3
CAS No.
SMILES

OC1=C(C)C2=CC=C3[C@@]4(C)CC[C@@]5(C)CC[C@@](C)(C(NCCCN6C=CN=C6)=O)C[C@]([H])5[C@@](C)4CC[C@](C)3C2=CC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LC-PDin06 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-PDin062027514-32-3Reactive Oxygen Species (ROS)InhibitorsPRDX1ROSAntiproliferativeCelastrolSW620 cellsHCT116 cellsMKN45 cellsInhibitorinhibitorinhibit

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