PRDX1 - peroxiredoxin 1 Gene

Also Known as PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5052

About PRDX1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,511,051-45,522,890 (from NCBI)

This gene has 6 transcripts (splice variants), 246 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues.

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the Antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in Cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

PRDX1 Products (4)

mRNA Protein Name
NM_001202431.2 NP_001189360.1 peroxiredoxin-1
NM_002574.4 NP_002565.1 peroxiredoxin-1
NM_181696.3 NP_859047.1 peroxiredoxin-1
NM_181697.3 NP_859048.1 peroxiredoxin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peroxidase activity IDA
IDA: Inferred from direct assay
11986303 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15105503 GOA
enables thioredoxin peroxidase activity IDA
IDA: Inferred from direct assay
18606987 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
11986303 GOA
involved in hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
18606987 GOA
involved in natural killer cell activation IDA
IDA: Inferred from direct assay
8462106 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17603937 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17603937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX1 Protein Structure

AhpC-TSA

AhpC-TSA: AhpC/TSA family (8 - 141)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (162 - 197)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

peroxiredoxin-1

  • epididymis secretory sperm binding protein

PRDX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRDX1 Q06830 DPP9 Homo sapiens Q86TI2-2
Validated Y2H
32814053
Intra
PRDX1 Q06830 DPP9 Homo sapiens Q86TI2-2
Y2H Pooling
32814053
Intra
PRDX1 Q06830 DPP9 Homo sapiens Q86TI2-2
Y2H Array
32814053
Intra
PRDX1 Q06830 PRDX4 Homo sapiens Q13162
Y2H
21988832
Intra
PRDX1 Q06830 STK4 Homo sapiens Q13043
Anti Tag CoIP
23386615
Intra
PRDX1 Q06830 STK4 Homo sapiens Q13043
Y2H
23386615
Intra
PRDX1 Q06830 STK4 Homo sapiens Q13043
Pull Down
23386615
Intra
PRDX1 Q06830 STK4 Homo sapiens Q13043
Protein Kinase Assay
23386615
Intra
PRDX1 Q06830 AR Homo sapiens P10275
Anti Bait CoIP
17909037
Intra
PRDX1 Q06830 PTEN Homo sapiens P60484
Anti Bait CoIP
19369943
Intra
PRDX1 Q06830 PTEN Homo sapiens P60484
Anti Tag CoIP
19369943
Intra
PRDX1 Q06830 PTEN Homo sapiens P60484
Pull Down
19369943
Intra
PRDX1 Q06830 TERF1 Homo sapiens P54274
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX1 Proteins

Cat. No. Product Name Accession Purity
HY-P71231 PRDX1/Peroxiredoxin-1 Protein, Human (His) Q06830 (M1-K199) ≥ 95%, as determined by reducing SDS-PAGE.

PRDX1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80782 Peroxiredoxin 1 Antibody (YA692) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80782A Peroxiredoxin 1 Antibody (YA692)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P85678 Peroxiredoxin 1 Antibody (YA5370) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P86506 Peroxiredoxin 1 Antibody (YA6198) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Methylmalonic Aciduria And Homocystinuria, Cblc Type

  • MAHCC

  • Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase

  • Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic

  • Methylmalonic Aciduria And Homocystinuria Type Cblc

  • Cobalamin C Disease

  • Methylmalonic Acidemia With Homocystinuria Cblc

  • Methylmalonic Acidemia And Homocystinuria, Cblc Type

  • Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive

  • Cobalamin C Deficiency

  • Methylmalonic Acidemia With Homocystinuria, Type Cblc

  • Cblc Defect

  • Cobalamin C Defect

  • Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc

  • Methylmalonic Aciduria With Homocystinuria, Type Cblc

  • Methylmalonic Acidemia And Homocystinuria Cblc Type

  • Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive

  • Aciduria, Methylmalonic, And Homocystinuria, Cblc Type

  • Methylmalonic Acidemia With Homocystinuria
Anthrax Disease

  • Anthrax

  • Ragpicker'S Disease

  • Black Baine

  • Malignant Edema

  • Malignant Pustule

  • Siberian Plague

  • Wool Sorter'S Disease

  • Gas Gangrene

  • Cutaneous Anthrax

  • Anthrax Infection

  • Splenic Fever
Cutaneous Anthrax

  • Anthrax, Skin Type

  • Skin Anthrax
Inhalation Anthrax

  • Pulmonary Anthrax

  • Respiratory Anthrax

  • Inhalational Anthrax

  • Wool-Sorters' Disease

  • Woolsorters' Disease

  • Inhalation Anthrax Disease

  • Respiratory Anthrax Disease
Gastrointestinal Anthrax
Parkinson Disease 17

  • PARK17

  • Parkinson'S Disease 17

  • Autosomal Dominant Parkinson Disease 17

  • Parkinson Disease, Type 17
Gastrointestinal Tularemia

  • Enteric Tularemia

  • Intestinal Tularaemia
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149394 PRDX1-IN-1 98.04% Unkown
HY-122936 Tanshindiol C 98.47% Unkown
HY-171272 PRDX1-IN-3 99.52% Unkown
HY-RS11074 PRDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158368 PRDX1-IN-2 / Unkown
HY-174412 LC-PDin06 Inhibitor / Unkown
HY-182287 PRDX1-IN-4 / Unkown
HY-182308 LC-PDA-01 Inhibitor / Unkown
HY-N14780 Pochonin D / Unkown
HY-RS16694 Prdx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23129 Prdx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRDX1 MGD MGI:99523
Rattus norvegicus PRDX1 RGD RGD:620039
Macaca mulatta PRDX1 VGNC VGNC:100047
Felis catus PRDX1 VGNC VGNC:107605
Bos taurus PRDX1 VGNC VGNC:33299
Others PRDX1 NCBI