Pde1a - phosphodiesterase 1A, calmodulin-dependent Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18573

About Pde1a

Chromosome 2: 79,664,797-79,959,802 reverse strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 208 orthologues, 20 paralogues and is associated with 15 phenotypes. Biased expression in cortex adult (RPKM 19.1), frontal lobe adult (RPKM 12.1) and 8 other tissues.

Summary

Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in signal transduction. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Pde1a Products (8)

mRNA Protein Name
NM_001009979.1 NP_001009979.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_001355142.2 NP_001342071.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 12
NM_016744.4 NP_058024.2 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001355140.1 NP_001342069.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001355144.1 NP_001342073.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 13
NM_001355141.1 NP_001342070.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001009978.1 NP_001009978.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7
NM_001159582.1 NP_001153054.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
15901640 MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
15901640 MGI
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
15901640 MGI
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
15901640 MGI
Cellular Component GO Annotation Evidence References Source
located in sperm flagellum IDA
IDA: Inferred from direct assay
15901640 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde1a Protein Structure

PDEase_I_N

PDEase_I_N: pfam08499 (72 - 132)

PDEase_I

PDEase_I: pfam00233 (217 - 438)

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  • 545 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

  • 61 kDa Cam-PDE

  • cam-PDE 1A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-103493 TAK-915 Inhibitor 99.57% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10208 PDE1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde1a NCBI NCBI:5136