2. Gene
  3. PDE1A - phosphodiesterase 1A Gene

PDE1A - phosphodiesterase 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A

Gene ID: 5136 | Gene type: protein coding

About PDE1A

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,140,041-182,716,797 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 20 paralogues. Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues.

Summary

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/Calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by Calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

PDE1A Products(25)

mRNA Protein Name
NM_001395269.1 NP_001382198.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 11
NM_001395265.2 NP_001382194.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 8
NM_001258313.3 NP_001245242.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 4
XM_017004294.3 XP_016859783.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2
NM_001395259.2 NP_001382188.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395266.1 NP_001382195.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_001258314.3 NP_001245243.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 5
XM_011511324.4 XP_011509626.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3
XM_047444688.1 XP_047300644.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4
XM_011511325.4 XP_011509627.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5
NM_001395260.2 NP_001382189.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395262.1 NP_001382191.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395267.1 NP_001382196.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_005019.7 NP_005010.2 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395264.1 NP_001382193.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7
NM_001395268.1 NP_001382197.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 10
NM_001003683.3 NP_001003683.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395261.2 NP_001382190.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001258312.3 NP_001245241.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3
XM_011511326.3 XP_011509628.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6
XM_011511323.3 XP_011509625.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1
XR_007076388.1
NM_001395258.2 NP_001382187.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395263.1 NP_001382192.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001363871.4 NP_001350800.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 6

PDE1A Protein Structure

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (73 - 133)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (218 - 446)

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  • 535 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

61 kDa Cam-PDE

calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase

phosphodiesterase 1A, calmodulin-dependent

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.54% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% Unkown
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10208 PDE1A Human Pre-designed siRNA Set A / Unkown
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A / Unkown
HY-120741 PF-04822163 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDE1A VGNC VGNC:44348
Mus musculus PDE1A MGD MGI:1201792
Rattus norvegicus PDE1A RGD RGD:68329
Macaca mulatta PDE1A VGNC VGNC:75909
Bos taurus PDE1A VGNC VGNC:32671
Felis catus PDE1A VGNC VGNC:68752