Pdk2 - pyruvate dehydrogenase kinase, isoenzyme 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18604

Summary

Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including Insulin Receptor signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; and regulation of gluconeogenesis. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of mitochondrial pyruvate dehydrogenase complex. Is expressed in heart. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pdk2 Products (2)

mRNA Protein Name
NM_001361915.1 NP_001348844.1 pyruvate dehydrogenase kinase, isoenzyme 2 isoform 2
NM_133667.2 NP_598428.2 pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
IMP: Inferred from mutant phenotype
22360721 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to nutrient IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
22360721 MGI
acts upstream of or within regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
23357539 MGI
involved in regulation of cellular ketone metabolic process IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
22360721 MGI
involved in regulation of pH IMP
IMP: Inferred from mutant phenotype
22360721 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
21190881 MGI
part of pyruvate dehydrogenase complex IDA
IDA: Inferred from direct assay
21190881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate dehydrogenase kinase, isoenzyme 2

  • PDH kinase 2

  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

  • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial

  • pyruvate dehydrogenase 2

  • pyruvate dehydrogenase kinase, isozyme 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12492 VER-246608 Inhibitor 99.10% Unkown
HY-121744 PS10 Inhibitor 98.51% Unkown
HY-19564 JX06 99.78% Unkown
HY-18676B ILK-IN-2 99.41% Unkown
HY-RS10276 PDK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16924 Pdk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23367 Pdk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdk2 NCBI NCBI:5164