Prkce - protein kinase C, epsilon Gene

Also Known as Pkce; PKC[e]; PKCepsilon; 5830406C15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18754

About Prkce

Chromosome 17: 86,475,213-86,965,347 forward strand.GRCm39:CM001010.3

This gene has 5 transcripts (splice variants), 312 orthologues, 9 paralogues and is associated with 15 phenotypes. Broad expression in frontal lobe adult (RPKM 22.3), cortex adult (RPKM 2.6) and 19 other tissues.

Summary

Enables several functions, including 14-3-3 protein binding activity; actin monomer binding activity; and calcium-independent protein kinase C activity. Involved in several processes, including TRAM-dependent Toll-like Receptor 4 signaling pathway; positive regulation of actin filament polymerization; and positive regulation of fibroblast migration. Acts upstream of or within several processes, including cellular response to alcohol; positive regulation of cell communication; and regulation of secretion. Located in several cellular components, including cytosol; mitochondrion; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; neural retina; and salivary gland. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Prkce Products (1)

mRNA Protein Name
NM_011104.3 NP_035234.1 protein kinase C epsilon type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IPI
IPI: Inferred from physical interaction
18604201 MGI
enables actin monomer binding IDA
IDA: Inferred from direct assay
11746497 MGI
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10879655 MGI
enables ethanol binding IDA
IDA: Inferred from direct assay
19432558 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11139474 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17875639 MGI
enables signaling receptor activator activity IDA
IDA: Inferred from direct assay
17875639 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IDA
IDA: Inferred from direct assay
11884367 MGI
involved in TRAM-dependent toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
16757566 MGI
acts upstream of cell-substrate adhesion IGI
IGI: Inferred from genetic interaction
15949469 MGI
acts upstream of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
15949469 MGI
acts upstream of or within cellular response to ethanol IGI
IGI: Inferred from genetic interaction
17875639 MGI
acts upstream of or within cellular response to hypoxia IDA
IDA: Inferred from direct assay
18070622 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IDA
IDA: Inferred from direct assay
23479225 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12837755 MGI
acts upstream of insulin secretion IMP
IMP: Inferred from mutant phenotype
12837755 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11696589 MGI
involved in lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16757566 MGI
acts upstream of or within locomotory exploration behavior IGI
IGI: Inferred from genetic interaction
17908177 MGI
acts upstream of or within macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
11696589 MGI
acts upstream of mucus secretion IMP
IMP: Inferred from mutant phenotype
17728398 MGI
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
25470454 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
11884367 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
11696589 MGI
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
11746497 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
11696589 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IGI
IGI: Inferred from genetic interaction
15949469 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
15949469 MGI
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
16270034 MGI
acts upstream of or within positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
12837755 MGI
acts upstream of or within positive regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
19401415 MGI
acts upstream of or within positive regulation of mucus secretion IMP
IMP: Inferred from mutant phenotype
17728398 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17875639 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12551921 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19401415 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
19401415 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
11940581 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
23479225 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
15905535 MGI
acts upstream of or within response to morphine IMP
IMP: Inferred from mutant phenotype
16899053 MGI
acts upstream of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17875639 MGI
Cellular Component GO Annotation Evidence References Source
colocalizes with Golgi apparatus IDA
IDA: Inferred from direct assay
17611075 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
17611075 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14613966 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11884367 MGI
located in membrane IDA
IDA: Inferred from direct assay
16270034 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14613966 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17611075 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkce Protein Structure

C2_PKC_epsilon

C2_PKC_epsilon: cd04014 (2 - 134)

C1_nPKC_epsilon-like_rpt1

C1_nPKC_epsilon-like_rpt1: cd20835 (160 - 223)

C1_nPKC_epsilon-like_rpt2

C1_nPKC_epsilon-like_rpt2: cd20838 (240 - 294)

STKc_nPKC_epsilon

STKc_nPKC_epsilon: cd05591 (411 - 731)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
Protein Preferred Names Protein Names

protein kinase C epsilon type

  • PCK epsilon

  • nPKC-epsilon

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1803 Protein Kinase C Peptide Substrate / Unkown
HY-RS11125 PRKCE Human Pre-designed siRNA Set A / Unkown
HY-RS11126 Prkce Mouse Pre-designed siRNA Set A / Unkown
HY-RS11127 Prkce Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkce NCBI NCBI:5581