PRKCE - protein kinase C epsilon Gene

Also Known as PKCE; nPKC-epsilon

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5581

About PRKCE

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:45,651,279-46,187,990 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 9 paralogues. Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, Apoptosis, cardioprotection from ischemia, heat shock response, as well as Insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PRKCE Products (23)

mRNA	Protein	Name
XM_011532981.4	XP_011531283.1	protein kinase C epsilon type isoform X4
XM_011532983.3	XP_011531285.1	protein kinase C epsilon type isoform X9
XM_047445096.1	XP_047301052.1	protein kinase C epsilon type isoform X2
XR_007078551.1
XM_047445098.1	XP_047301054.1	protein kinase C epsilon type isoform X2
XM_017004488.3	XP_016859977.1	protein kinase C epsilon type isoform X3
XM_047445097.1	XP_047301053.1	protein kinase C epsilon type isoform X2
XR_939695.3
XM_047445094.1	XP_047301050.1	protein kinase C epsilon type isoform X2
XM_047445095.1	XP_047301051.1	protein kinase C epsilon type isoform X2
XM_006712050.4	XP_006712113.1	protein kinase C epsilon type isoform X8
XM_047445099.1	XP_047301055.1	protein kinase C epsilon type isoform X3
XM_011532975.4	XP_011531277.1	protein kinase C epsilon type isoform X2
XM_011532980.4	XP_011531282.1	protein kinase C epsilon type isoform X4
XM_005264428.2	XP_005264485.1	protein kinase C epsilon type isoform X1
XM_017004490.3	XP_016859979.1	protein kinase C epsilon type isoform X4
XM_011532982.3	XP_011531284.1	protein kinase C epsilon type isoform X5
XM_011532971.4	XP_011531273.1	protein kinase C epsilon type isoform X2
XM_005264431.5	XP_005264488.1	protein kinase C epsilon type isoform X6
NM_005400.3	NP_005391.1	protein kinase C epsilon type
XM_011532978.3	XP_011531280.1	protein kinase C epsilon type isoform X3
XM_017004492.3	XP_016859981.1	protein kinase C epsilon type isoform X7
XM_047445100.1	XP_047301056.1	protein kinase C epsilon type isoform X10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18556656	GOA
enables enzyme activator activity	IMP IMP: Inferred from mutant phenotype	18556656	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	18556656	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15632189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16810323	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19542546	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15695813	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15695813	GOA
involved in positive regulation of cellular glucuronidation	IMP IMP: Inferred from mutant phenotype	18556656	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	18604201	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	17603037	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	17603037	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	34593629	GOA
acts upstream of toxin catabolic process	IDA IDA: Inferred from direct assay	18556656	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17603037	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18556656	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15632189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCE Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
737 a.a.

Protein Preferred Names	Protein Names
protein kinase C epsilon type

PRKCE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKCE	Q02156	PRKCA	Homo sapiens	P17252	Anti Bait CoIP	16810323
Intra	PRKCE	Q02156	RPS6KA2	Homo sapiens	Q15349	Anti Bait CoIP	16810323
Intra	PRKCE	Q02156	YWHAZ	Homo sapiens	P63104	ITC	19662078
Intra	PRKCE	Q02156	YWHAZ	Homo sapiens	P63104	GMS	19662078
Intra	PRKCE	Q02156	YWHAZ	Homo sapiens	P63104	X-Ray Diffraction	19662078
Intra	PRKCE	Q02156	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	31980649
Intra	PRKCE	Q02156	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	PRKCE	Q02156	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	PRKCE	Q02156	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKCE	Q02156	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	31980649
Intra	PRKCE	Q02156	BRAF	Homo sapiens	P15056	Anti Bait CoIP	21625473
Intra	PRKCE	Q02156	BRAF	Homo sapiens	P15056	Anti Bait CoIP	16810323
Intra	PRKCE	Q02156	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	PRKCE	Q02156	MAPKAP1	Homo sapiens	Q9BPZ7	Anti Bait CoIP	28934384
Intra	PRKCE	Q02156	MAPKAP1	Homo sapiens	Q9BPZ7	Anti Tag CoIP	28934384
Intra	PRKCE	Q02156	IL32	Homo sapiens	C6GKH1	Anti Tag CoIP	24996056

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKCE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71208	PRKCE Protein, Human (His)	Q02156 (Q580-P737)	≥ 90%, as determined by reducing SDS-PAGE.

PRKCE Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80434	PKC epsilon Antibody (YA127)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ischemia	Acute Coronary Syndrome
Alcoholic Neuropathy	Alcoholic Polyneuropathy Alcohol-Related Polyneuropathy Alcohol-Induced Polyneuropathy Alcoholic Peripheral Neuropathy
Short Syndrome	Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay Aarskog-Ose-Pande Syndrome Lipodystrophy, Partial, With Rieger Anomaly And Short Stature Lipodystrophy-Rieger Anomaly-Diabetes Syndrome Rieger Anomaly-Partial Lipodystrophy Syndrome Partial Lipodystrophy With Rieger Anomaly And Short Stature Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay Growth Retardation-Rieger Anomaly Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay SHORTS
Rift Valley Fever	Rfv - [Rift Valley Fever]
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P1803	Protein Kinase C Peptide Substrate	/	Unkown
HY-RS11125	PRKCE Human Pre-designed siRNA Set A	/	Unkown
HY-RS11126	Prkce Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11127	Prkce Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRKCE	RGD	RGD:61925
Bos taurus	PRKCE	VGNC	VGNC:33330
Felis catus	PRKCE	VGNC	VGNC:69060
Canis familiaris	PRKCE	VGNC	VGNC:44980
Macaca mulatta	PRKCE	VGNC	VGNC:76412
Mus musculus	PRKCE	MGD	MGI:97599
Others	PRKCE	NCBI