PRKCE - protein kinase C epsilon Gene

Homo sapiens

Also known as PKCE; nPKC-epsilon

Gene ID: 5581 | Gene type: protein coding

About PRKCE

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:45,651,279-46,187,990 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 9 paralogues. Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, Apoptosis, cardioprotection from ischemia, heat shock response, as well as Insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PRKCE Products(23)

mRNA	Protein	Name
XM_011532981.4	XP_011531283.1	protein kinase C epsilon type isoform X4
XM_011532983.3	XP_011531285.1	protein kinase C epsilon type isoform X9
XM_047445096.1	XP_047301052.1	protein kinase C epsilon type isoform X2
XR_007078551.1
XM_047445098.1	XP_047301054.1	protein kinase C epsilon type isoform X2
XM_017004488.3	XP_016859977.1	protein kinase C epsilon type isoform X3
XM_047445097.1	XP_047301053.1	protein kinase C epsilon type isoform X2
XR_939695.3
XM_047445094.1	XP_047301050.1	protein kinase C epsilon type isoform X2
XM_047445095.1	XP_047301051.1	protein kinase C epsilon type isoform X2
XM_006712050.4	XP_006712113.1	protein kinase C epsilon type isoform X8
XM_047445099.1	XP_047301055.1	protein kinase C epsilon type isoform X3
XM_011532975.4	XP_011531277.1	protein kinase C epsilon type isoform X2
XM_011532980.4	XP_011531282.1	protein kinase C epsilon type isoform X4
XM_005264428.2	XP_005264485.1	protein kinase C epsilon type isoform X1
XM_017004490.3	XP_016859979.1	protein kinase C epsilon type isoform X4
XM_011532982.3	XP_011531284.1	protein kinase C epsilon type isoform X5
XM_011532971.4	XP_011531273.1	protein kinase C epsilon type isoform X2
XM_005264431.5	XP_005264488.1	protein kinase C epsilon type isoform X6
NM_005400.3	NP_005391.1	protein kinase C epsilon type
XM_011532978.3	XP_011531280.1	protein kinase C epsilon type isoform X3
XM_017004492.3	XP_016859981.1	protein kinase C epsilon type isoform X7
XM_047445100.1	XP_047301056.1	protein kinase C epsilon type isoform X10

PRKCE Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
737 a.a.

Protein Preferred Names

Protein Names

protein kinase C epsilon type

Recombinant PRKCE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71208	PKCE Protein, Human (His)	Q02156 (Q580-P737)	≥95%

Related Diseases

Diseases

Alias

Ischemia

Acute Coronary Syndrome

Alcoholic Neuropathy

Alcoholic Polyneuropathy	Alcohol-Related Polyneuropathy
Alcohol-Induced Polyneuropathy	Alcoholic Peripheral Neuropathy

Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay	Aarskog-Ose-Pande Syndrome
Lipodystrophy, Partial, With Rieger Anomaly And Short Stature	Lipodystrophy-Rieger Anomaly-Diabetes Syndrome
Rieger Anomaly-Partial Lipodystrophy Syndrome	Partial Lipodystrophy With Rieger Anomaly And Short Stature
Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay	Growth Retardation-Rieger Anomaly
Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay	SHORTS

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11125	PRKCE Human Pre-designed siRNA Set A	/	Unkown
HY-RS11126	Prkce Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11127	Prkce Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRKCE	RGD	RGD:61925
Bos taurus	PRKCE	VGNC	VGNC:33330
Felis catus	PRKCE	VGNC	VGNC:69060
Canis familiaris	PRKCE	VGNC	VGNC:44980
Macaca mulatta	PRKCE	VGNC	VGNC:76412
Mus musculus	PRKCE	MGD	MGI:97599
Others	PRKCE	NCBI

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