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Ppara - peroxisome proliferator activated receptor alpha Gene

Also Known as Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19013

About Ppara

Chromosome 15: 85,619,184-85,687,020 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 455 orthologues, 19 paralogues and is associated with 52 phenotypes. Broad expression in liver adult (RPKM 11.2), kidney adult (RPKM 8.7) and 15 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lipid binding activity. Involved in several processes, including negative regulation of appetite; positive regulation of fatty acid oxidation; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of cellular biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara Products (2)

mRNA	Protein	Name
NM_001113418.1	NP_001106889.1	peroxisome proliferator-activated receptor alpha
NM_011144.6	NP_035274.2	peroxisome proliferator-activated receptor alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	16271724	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12015306	MGI
enables lipid binding	IDA IDA: Inferred from direct assay	12955147	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9325263	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16271724	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	12802337	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	15232616	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	23209793	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	20159955	MGI
acts upstream of or within enamel mineralization	IMP IMP: Inferred from mutant phenotype	19320717	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	12485431	MGI
acts upstream of or within fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	9488698	MGI
acts upstream of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	15232616	MGI
involved in negative regulation of appetite	IMP IMP: Inferred from mutant phenotype	12955147	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15007068	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12955147	MGI
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	15639194	MGI
acts upstream of or within positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	15232616	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8041794	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20385772	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16571721	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23209793	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	20159955	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15313227	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	11514592	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppara Protein Structure

NR_DBD_Ppar

NR_LBD_PPAR

0
100
200
300
400
468 a.a.

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor alpha	nuclear receptor subfamily 1 group C member 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14728	Aleglitazar	Agonist	99.74%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10919	PPARA Human Pre-designed siRNA Set A		/	Unkown
HY-RS10920	Ppara Mouse Pre-designed siRNA Set A		/	Unkown
HY-121579	L-764406	Agonist	/	Unkown
HY-RS10921	Ppara Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppara	NCBI	NCBI:5465