2. Gene
  3. Ppara - peroxisome proliferator activated receptor alpha Gene

Ppara - peroxisome proliferator activated receptor alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik

Gene ID: 19013 | Gene type: protein coding

About Ppara

Chromosome 15: 85,619,184-85,687,020 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 455 orthologues, 19 paralogues and is associated with 52 phenotypes. Broad expression in liver adult (RPKM 11.2), kidney adult (RPKM 8.7) and 15 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lipid binding activity. Involved in several processes, including negative regulation of appetite; positive regulation of fatty acid oxidation; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of cellular biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara Products(2)

mRNA Protein Name
NM_001113418.1 NP_001106889.1 peroxisome proliferator-activated receptor alpha
NM_011144.6 NP_035274.2 peroxisome proliferator-activated receptor alpha

Ppara Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (100 - 183)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (200 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor alpha

nuclear receptor subfamily 1 group C member 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14728 Aleglitazar Agonist 99.74% Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10919 PPARA Human Pre-designed siRNA Set A / Unkown
HY-RS10920 Ppara Mouse Pre-designed siRNA Set A / Unkown
HY-RS10921 Ppara Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppara NCBI NCBI:5465