Dusp1 - dual specificity phosphatase 1 Gene

Also Known as erp; MKP1; mkp-1; 3CH134; Ptpn16

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19252

Summary

Enables mitogen-activated protein kinase binding activity and phosphoprotein Phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human DUSP1 (dual specificity Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dusp1 Products (1)

mRNA Protein Name
NM_013642.3 NP_038670.1 dual specificity protein phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase tyrosine/serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
8221888 MGI
enables mitogen-activated protein kinase binding IDA
IDA: Inferred from direct assay
8221888 MGI
enables mitogen-activated protein kinase binding IPI
IPI: Inferred from physical interaction
8221888 MGI
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
8355678 MGI
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
8355678 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
8221888 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8355678 MGI
involved in peptidyl-serine dephosphorylation IMP
IMP: Inferred from mutant phenotype
8355678 MGI
involved in peptidyl-threonine dephosphorylation IMP
IMP: Inferred from mutant phenotype
8221888 MGI
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
8221888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 1

  • MAP kinase phosphatase 1

  • mitogen-activated protein kinase phosphatase-1

  • protein tyrosine phosphatase, non-receptor type 16

  • protein-tyrosine phosphatase 3CH134

  • protein-tyrosine phosphatase ERP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2179 Hypaphorine Inhibitor 99.93% Unkown
HY-RS04050 DUSP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04053 DUSP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16828 Dusp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23270 Dusp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp1 NCBI NCBI:1843