Rac2 - Rac family small GTPase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19354

Summary

Enables GTPase activity and protein kinase regulator activity. Involved in positive regulation of lamellipodium assembly; regulation of leukocyte activation; and regulation of leukocyte chemotaxis. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; actin Cytoskeleton organization; and cell projection assembly. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]

Rac2 Products (1)

mRNA Protein Name
NM_009008.3 NP_033034.1 ras-related C3 botulinum toxin substrate 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
15249579 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18264091 MGI
enables protein kinase regulator activity IMP
IMP: Inferred from mutant phenotype
10843388 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
11435472 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11435472 MGI
acts upstream of or within cell projection assembly IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within erythrocyte enucleation IMP
IMP: Inferred from mutant phenotype
18264091 MGI
acts upstream of mast cell proliferation IGI
IGI: Inferred from genetic interaction
11435472 MGI
acts upstream of mast cell proliferation IMP
IMP: Inferred from mutant phenotype
11435472 MGI
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
19625648 MGI
acts upstream of or within positive regulation of mast cell proliferation IGI
IGI: Inferred from genetic interaction
11435472 MGI
acts upstream of or within positive regulation of mast cell proliferation IMP
IMP: Inferred from mutant phenotype
11435472 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
19625648 MGI
involved in regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
11581314 MGI
involved in regulation of mast cell chemotaxis IMP
IMP: Inferred from mutant phenotype
10843388 MGI
involved in regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
10843388 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12176888 MGI
located in membrane IDA
IDA: Inferred from direct assay
12176888 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
12176888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related C3 botulinum toxin substrate 2

  • EN-7 protein

  • RAS-related C3 botulinum substrate 2

  • p21-Rac2

  • protein EN-7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16659 EHT 1864 Inhibitor 99.85% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-132316S (rac)-2,4-O-Dimethylzearalenone-d6 / Unkown
HY-RS11592 RAC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W051624S (Rac)-2-Aminothiazoline-4-carboxylic acid-13C,15N2 / Unkown
HY-W704952 rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen-d6 / Unkown
HY-W756586 Rac 2-stearoyl-3-chloropropanediol-13C3 / Unkown
HY-W756589 Rac 2-linolenoyl-3-chloropropanediol-13C3 / Unkown
HY-143681S (Rac)-2-Palmitoyl-3-chloropropanediol-d5 / Unkown
HY-RS17270 Rac2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23724 Rac2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010590S (Rac)-2-Aminobutyric acid-d3 / Unkown
HY-W440982A (Rac)-SOPC / Unkown
HY-W778187 rac 2-Oleoyl-3-chloropropanediol-d5,95% / Unkown
HY-W778189 rac-2-Linoleoyl-3-chloropropanediol-d5,95% / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rac2 NCBI NCBI:5880