MEGF6 - multiple EGF like domains 6 Gene

Homo sapiens

Also known as EGFL3

Gene ID: 1953 | Gene type: protein coding

About MEGF6

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:3,487,951-3,624,786 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues and 3 paralogues. Broad expression in skin (RPKM 15.1), lung (RPKM 6.0) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

MEGF6 Products(2)

mRNA	Protein	Name
NM_001409.4	NP_001400.3	multiple epidermal growth factor-like domains protein 6 isoform 1 precursor
NM_001410718.1	NP_001397647.1	multiple epidermal growth factor-like domains protein 6 isoform 2 precursor

MEGF6 Protein Structure

FXa_inhibition

EGF_CA

FXa_inhibition

Laminin_EGF

0
300
600
900
1200
1541 a.a.

Protein Preferred Names

Protein Names

multiple epidermal growth factor-like domains protein 6

EGF-like protein 3

Related Diseases

Diseases

Alias

Sapho Syndrome

Acquired Hyperostosis Syndrome	Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome
Synovitis Acne Pustulosis Hyperostosis Osteitis	Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis
Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome	Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome
Pustulo-Psoriatic Hyperostotic Spondylarthritis	Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08316	MEGF6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MEGF6	VGNC	VGNC:100010
Canis familiaris	MEGF6	VGNC	VGNC:53423
Bos taurus	MEGF6	VGNC	VGNC:58605
Mus musculus	MEGF6	MGD	MGI:1919351
Felis catus	MEGF6	VGNC	VGNC:63444
Rattus norvegicus	MEGF6	RGD	RGD:621188

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