MEGF6 - multiple EGF like domains 6 Gene

Also Known as EGFL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1953

About MEGF6

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:3,487,951-3,624,786 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues and 3 paralogues. Broad expression in skin (RPKM 15.1), lung (RPKM 6.0) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

MEGF6 Products (2)

mRNA Protein Name
NM_001409.4 NP_001400.3 multiple epidermal growth factor-like domains protein 6 isoform 1 precursor
NM_001410718.1 NP_001397647.1 multiple epidermal growth factor-like domains protein 6 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21078624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEGF6 Protein Structure

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (165 - 200)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (206 - 242)

EGF_CA

EGF_CA: Calcium-binding EGF domain (285 - 324)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (335 - 370)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (416 - 451)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (568 - 613)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (873 - 917)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (1132 - 1169)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (1175 - 1213)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (1348 - 1385)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1541 a.a.
Protein Preferred Names Protein Names

multiple epidermal growth factor-like domains protein 6

  • EGF-like protein 3

MEGF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MEGF6 O75095 ATXN7 Homo sapiens O15265
Y2H
21078624
Intra
MEGF6 O75095 CACNA1A Homo sapiens O00555
Pull Down
21078624
Intra
MEGF6 O75095 CACNA1A Homo sapiens O00555
Y2H
21078624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sapho Syndrome

  • Acquired Hyperostosis Syndrome

  • Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome

  • Synovitis Acne Pustulosis Hyperostosis Osteitis

  • Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis

  • Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome

  • Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome

  • Pustulo-Psoriatic Hyperostotic Spondylarthritis

  • Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08316 MEGF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22633 Megf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29148 Megf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MEGF6 VGNC VGNC:100010
Canis familiaris MEGF6 VGNC VGNC:53423
Bos taurus MEGF6 VGNC VGNC:58605
Mus musculus MEGF6 MGD MGI:1919351
Felis catus MEGF6 VGNC VGNC:63444
Rattus norvegicus MEGF6 RGD RGD:621188
Others MEGF6 NCBI