2. Gene
  3. Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p65; p65 NFkB; p65 NF-kappa B

Gene ID: 19697 | Gene type: protein coding

About Rela

Chromosome 19: 5,687,511-5,698,158 forward strand.GRCm39:CM001012.3

This gene has 7 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 47 phenotypes. Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela Products(3)

mRNA Protein Name
NM_001402548.1 NP_001389477.1 transcription factor p65 isoform p65 iso 3
NM_009045.5 NP_033071.1 transcription factor p65 isoform 1
NM_001365067.1 NP_001351996.1 transcription factor p65 isoform 2

Rela Protein Structure

RHD-n_RelA

RHD-n_RelA: cd07885 (18 - 186)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (193 - 289)

PHA03247

PHA03247: cl33720 (254 - 520)

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  • 549 a.a.
Protein Preferred Names Protein Names

transcription factor p65

avian reticuloendotheliosis viral (v-rel) oncogene homolog A

nuclear factor NF-kappa-B p65 subunit

nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11826 RELA Human Pre-designed siRNA Set A / Unkown
HY-RS11827 Rela Mouse Pre-designed siRNA Set A / Unkown
HY-RS11828 Rela Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rela NCBI NCBI:5970
Canis familiaris Rela NCBI NCBI:483729
Macaca fascicularis Rela NCBI NCBI:101867324
Canis lupus familiaris Rela NCBI
Rattus norvegicus Rela NCBI NCBI:309165
Macaca mulatta Rela NCBI NCBI:715919