WDR90 - WD repeat domain 90 Gene

Also Known as POC16; C16orf15; C16orf16; C16orf17; C16orf18; C16orf19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 197335

About WDR90

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:648,979-667,830 (from NCBI)

This gene has 25 transcripts (splice variants), 169 orthologues and 9 paralogues. Broad expression in testis (RPKM 12.0), bone marrow (RPKM 4.3) and 23 other tissues.

Summary

Involved in cilium assembly. Located in centriole. [provided by Alliance of Genome Resources, Apr 2022]

WDR90 Products (1)

mRNA Protein Name
NM_145294.5 NP_660337.3 WD repeat-containing protein 90

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
28781053 GOA
Cellular Component GO Annotation Evidence References Source
located in centriole IDA
IDA: Inferred from direct assay
28781053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR90 Protein Structure

DUF667

DUF667: Protein of unknown function (DUF667) (3 - 181)

WD40

WD40: WD domain, G-beta repeat (615 - 644)

Nup160

Nup160: Nucleoporin Nup120/160 (673 - 736)

WD40

WD40: WD domain, G-beta repeat (965 - 991)

WD40

WD40: WD domain, G-beta repeat (1152 - 1192)

WD40

WD40: WD domain, G-beta repeat (1428 - 1462)

WD40

WD40: WD domain, G-beta repeat (1479 - 1511)

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  • 1500
  • 1748 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 90

WDR90 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR90 Q96KV7 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Loeys-Dietz Syndrome 2

  • LDS2

  • Aat3

  • Marfan Syndrome Type 2

  • Aortic Aneurysm, Familial Thoracic 3

  • Marfan Syndrome Type Ii

  • Loeys-Dietz Syndrome Type 2

  • Mfs2

  • Marfan Syndrome, Type Ii, Formerly

  • Familial Throacic Aortic Aneurysm 3

  • Familial Aortic Aneurysm Thoracic Type 3

  • Taad2

  • Thoracic Aortic Aneurysms And Dissection 2

  • Aneurysm, Aortic, Thoracic, Familial, Type 3

  • Loeys-Dietz Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15802 WDR90 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WDR90 VGNC VGNC:48397
Rattus norvegicus WDR90 RGD RGD:7520481
Felis catus WDR90 VGNC VGNC:107831
Mus musculus WDR90 MGD MGI:1921267
Bos taurus WDR90 VGNC VGNC:36926
Others WDR90 NCBI